Lung Microbiome in Cystic Fibrosis
The defective mucociliary clearance due to CFTR malfunctioning causes predisposition to the colonization of pathogens responsible for the recurrent inflammation and rapid deterioration of lung function in patients with cystic fibrosis (CF). This has also a profound effect on the lung microbiome comp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/2/94 |
| _version_ | 1797406833602723840 |
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| author | Filippo Scialo Felice Amato Gustavo Cernera Monica Gelzo Federica Zarrilli Marika Comegna Lucio Pastore Andrea Bianco Giuseppe Castaldo |
| author_facet | Filippo Scialo Felice Amato Gustavo Cernera Monica Gelzo Federica Zarrilli Marika Comegna Lucio Pastore Andrea Bianco Giuseppe Castaldo |
| author_sort | Filippo Scialo |
| collection | DOAJ |
| description | The defective mucociliary clearance due to CFTR malfunctioning causes predisposition to the colonization of pathogens responsible for the recurrent inflammation and rapid deterioration of lung function in patients with cystic fibrosis (CF). This has also a profound effect on the lung microbiome composition, causing a progressive reduction in its diversity, which has become a common characteristic of patients affected by CF. Although we know that the lung microbiome plays an essential role in maintaining lung physiology, our comprehension of how the microbial components interact with each other and the lung, as well as how these interactions change during the disease’s course, is still at an early stage. Many challenges exist and many questions still to be answered, but there is no doubt that manipulation of the lung microbiome could help to develop better therapies for people affected by CF. |
| first_indexed | 2024-03-09T03:31:23Z |
| format | Article |
| id | doaj.art-4d27c7f5f8e24d7f97e2c4076c8576e3 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T03:31:23Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4d27c7f5f8e24d7f97e2c4076c8576e32023-12-03T14:54:12ZengMDPI AGLife2075-17292021-01-011129410.3390/life11020094Lung Microbiome in Cystic FibrosisFilippo Scialo0Felice Amato1Gustavo Cernera2Monica Gelzo3Federica Zarrilli4Marika Comegna5Lucio Pastore6Andrea Bianco7Giuseppe Castaldo8Dipartimento di Scienze Mediche Traslazionali, University of Campania “L. Vanvitelli”, 80131 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyDipartimento di Scienze Mediche Traslazionali, University of Campania “L. Vanvitelli”, 80131 Napoli, ItalyCEINGE, Biotecnologie Avanzate, 80145 Napoli, ItalyThe defective mucociliary clearance due to CFTR malfunctioning causes predisposition to the colonization of pathogens responsible for the recurrent inflammation and rapid deterioration of lung function in patients with cystic fibrosis (CF). This has also a profound effect on the lung microbiome composition, causing a progressive reduction in its diversity, which has become a common characteristic of patients affected by CF. Although we know that the lung microbiome plays an essential role in maintaining lung physiology, our comprehension of how the microbial components interact with each other and the lung, as well as how these interactions change during the disease’s course, is still at an early stage. Many challenges exist and many questions still to be answered, but there is no doubt that manipulation of the lung microbiome could help to develop better therapies for people affected by CF.https://www.mdpi.com/2075-1729/11/2/94cystic fibrosislungmicrobiomeCFTR |
| spellingShingle | Filippo Scialo Felice Amato Gustavo Cernera Monica Gelzo Federica Zarrilli Marika Comegna Lucio Pastore Andrea Bianco Giuseppe Castaldo Lung Microbiome in Cystic Fibrosis Life cystic fibrosis lung microbiome CFTR |
| title | Lung Microbiome in Cystic Fibrosis |
| title_full | Lung Microbiome in Cystic Fibrosis |
| title_fullStr | Lung Microbiome in Cystic Fibrosis |
| title_full_unstemmed | Lung Microbiome in Cystic Fibrosis |
| title_short | Lung Microbiome in Cystic Fibrosis |
| title_sort | lung microbiome in cystic fibrosis |
| topic | cystic fibrosis lung microbiome CFTR |
| url | https://www.mdpi.com/2075-1729/11/2/94 |
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