The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury
Abstract Acute kidney injury (AKI) is a common clinical condition associated with high morbidity and mortality. The pathogenesis of AKI has not been fully elucidated, with a lack of effective treatment. Renal tubular epithelial cells (TECs) play an important role in AKI, and their damage and repair...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-05-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-022-01034-0 |
| _version_ | 1811308253635674112 |
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| author | Zixian Li Zejian Liu Mianna Luo Xingyu Li Huixia Chen Siqiao Gong Minjie Zhang Yaozhi Zhang Huafeng Liu Xiaoyu Li |
| author_facet | Zixian Li Zejian Liu Mianna Luo Xingyu Li Huixia Chen Siqiao Gong Minjie Zhang Yaozhi Zhang Huafeng Liu Xiaoyu Li |
| author_sort | Zixian Li |
| collection | DOAJ |
| description | Abstract Acute kidney injury (AKI) is a common clinical condition associated with high morbidity and mortality. The pathogenesis of AKI has not been fully elucidated, with a lack of effective treatment. Renal tubular epithelial cells (TECs) play an important role in AKI, and their damage and repair largely determine the progression and prognosis of AKI. In recent decades, it has been found that the mitochondria, endoplasmic reticulum (ER), lysosomes, and other organelles in TECs are damaged to varying degrees in AKI, and that they can influence each other through various signaling mechanisms that affect the recovery of TECs. However, the association between these multifaceted signaling platforms, particularly between mitochondria and lysosomes during AKI remains unclear. This review summarizes the specific pathophysiological mechanisms of the main TECs organelles in the context of AKI, particularly the potential interactions among them, in order to provide insights into possible novel treatment strategies. |
| first_indexed | 2024-04-13T09:18:47Z |
| format | Article |
| id | doaj.art-4d28477a39cf49448d4c4023d4496f59 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-13T09:18:47Z |
| publishDate | 2022-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-4d28477a39cf49448d4c4023d4496f592022-12-22T02:52:40ZengNature Publishing GroupCell Death Discovery2058-77162022-05-018111210.1038/s41420-022-01034-0The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injuryZixian Li0Zejian Liu1Mianna Luo2Xingyu Li3Huixia Chen4Siqiao Gong5Minjie Zhang6Yaozhi Zhang7Huafeng Liu8Xiaoyu Li9Institute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityInstitute of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Affiliated Hospital of Guangdong Medical UniversityAbstract Acute kidney injury (AKI) is a common clinical condition associated with high morbidity and mortality. The pathogenesis of AKI has not been fully elucidated, with a lack of effective treatment. Renal tubular epithelial cells (TECs) play an important role in AKI, and their damage and repair largely determine the progression and prognosis of AKI. In recent decades, it has been found that the mitochondria, endoplasmic reticulum (ER), lysosomes, and other organelles in TECs are damaged to varying degrees in AKI, and that they can influence each other through various signaling mechanisms that affect the recovery of TECs. However, the association between these multifaceted signaling platforms, particularly between mitochondria and lysosomes during AKI remains unclear. This review summarizes the specific pathophysiological mechanisms of the main TECs organelles in the context of AKI, particularly the potential interactions among them, in order to provide insights into possible novel treatment strategies.https://doi.org/10.1038/s41420-022-01034-0 |
| spellingShingle | Zixian Li Zejian Liu Mianna Luo Xingyu Li Huixia Chen Siqiao Gong Minjie Zhang Yaozhi Zhang Huafeng Liu Xiaoyu Li The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury Cell Death Discovery |
| title | The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury |
| title_full | The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury |
| title_fullStr | The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury |
| title_full_unstemmed | The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury |
| title_short | The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury |
| title_sort | pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury |
| url | https://doi.org/10.1038/s41420-022-01034-0 |
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