Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability

Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability

(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10<sup>−6</sup> cm/s across Caco-2 colonic cells),...

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Bibliographic Details
Main Authors: Juseung Lee, Jong-Ju Lee, Seungyeol Lee, Linh Dinh, Hangyu Oh, Sharif Md Abuzar, Jun-Hyun Ahn, Sung-Joo Hwang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
apixaban
anticoagulation
solid dispersion
solubility enhancement
bioavailability enhancement
Online Access:https://www.mdpi.com/1999-4923/15/3/907

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