Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Abstract Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer. However, the mediators and mechanisms remain unclear. Methods Survival...

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Bibliographic Details
Main Authors: Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Exosomes
Adipocytes
Tumour progression
Online Access:http://link.springer.com/article/10.1186/s13046-019-1210-3

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