A Mouse Model of PPRV Infection for Elucidating Protective and Pathological Roles of Immune Cells

A Mouse Model of PPRV Infection for Elucidating Protective and Pathological Roles of Immune Cells

The study was aimed at developing an accessible laboratory animal model to elucidate protective and pathological roles of immune mediators during Peste des petits ruminants virus (PPRV) infection. It is because of the critical roles of type I IFNs in anti-viral defense, we assessed the susceptibilit...

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Main Authors: Yashu Sharma, Roman Sarkar, Ayush Jain, Sudhakar Singh, Chander Shekhar, Chandrasekar Shanmugam, Muthuchelvan Dhanavelu, Prabhakar Tembhurne, Rajeev Kaul, Sharvan Sehrawat
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
peste des petits ruminants virus
CD8 T cells
mouse model
class I epitopes
pathogenicity
IFNR KO
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.630307/full

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