SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study
Abstract Background French Polynesia (FP) comprises 75 inhabited islands scattered across five archipelagos. Between July and October 2021, the SARS-CoV-2 Delta variant triggered a much stronger second epidemic wave in FP than the original Wuhan strain, which was dominant from August 2020 to March 2...
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| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-17869-4 |
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| author | Vincent Mendiboure Iotefa Teiti Maite Aubry Anita Teissier Tuterarii Paoaafaite Jessica Vanhomwegen Jean-Claude Manuguerra Arnaud Fontanet Van-Mai Cao-Lormeau Yoann Madec |
| author_facet | Vincent Mendiboure Iotefa Teiti Maite Aubry Anita Teissier Tuterarii Paoaafaite Jessica Vanhomwegen Jean-Claude Manuguerra Arnaud Fontanet Van-Mai Cao-Lormeau Yoann Madec |
| author_sort | Vincent Mendiboure |
| collection | DOAJ |
| description | Abstract Background French Polynesia (FP) comprises 75 inhabited islands scattered across five archipelagos. Between July and October 2021, the SARS-CoV-2 Delta variant triggered a much stronger second epidemic wave in FP than the original Wuhan strain, which was dominant from August 2020 to March 2021. Although previous seroprevalence surveys made it possible to determine the proportion of the population infected by SARS-CoV-2 on the two most populated islands (Tahiti and Moorea) after the first (20.6% in Tahiti and 9.4% in Moorea) and second (57.7% in Tahiti) epidemic waves, no data are available for more remote islands. We used blood samples and personal data collected before, during, and after the second wave from inhabitants of several islands within the five archipelagos to assess the prevalence of SARS-CoV-2 infections and identify associated factors. Methods Blood samples and personal data were collected between April and December 2021 as part of the MATAEA study, a cross-sectional survey conducted on a random sample of the adult population representative of the five FP archipelagos and stratified by age and gender. IgG antibodies targeting the SARS-CoV-2 nucleocapsid (N) protein were detected using a recombinant antigen-based microsphere immunoassay. Factors associated with anti-SARS-CoV-2-N seropositivity were identified using logistic regression models. Results Of 1,120 participants, 503 (44.9%) tested positive for anti-SARS-CoV-2-N antibodies, corresponding to a weighted prevalence of 56.8% for the FP population aged 18–69 years. The seroprevalence increased from 21.9% to 62.1% before and during/after the Delta wave. Of these infections, only 28.4% had been diagnosed by health professionals. The odds of being seropositive were lower in males, participants recruited before the Delta wave, those who had never been married, those with a diagnosed respiratory allergy, smokers, and those vaccinated against COVID-19. Conclusions Our results confirm the high impact of the Delta wave in FP. By the end of 2021, 56.8% of the FP population aged 18–69 years had been infected by SARS-CoV-2; the majority of these infections went undetected. Individuals with respiratory allergies were found to be less susceptible to SARS-CoV-2 infection. |
| first_indexed | 2024-03-07T14:36:45Z |
| format | Article |
| id | doaj.art-4d2bccebcdc949489259ae076003e686 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-07T14:36:45Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-4d2bccebcdc949489259ae076003e6862024-03-05T20:35:27ZengBMCBMC Public Health1471-24582024-02-0124111210.1186/s12889-024-17869-4SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional studyVincent Mendiboure0Iotefa Teiti1Maite Aubry2Anita Teissier3Tuterarii Paoaafaite4Jessica Vanhomwegen5Jean-Claude Manuguerra6Arnaud Fontanet7Van-Mai Cao-Lormeau8Yoann Madec9Emerging Diseases Epidemiology Unit, Institut Pasteur, Université Paris CitéLaboratory of Research On Emerging Viral Diseases, Institut Louis MalardéLaboratory of Research On Emerging Viral Diseases, Institut Louis MalardéLaboratory of Research On Emerging Viral Diseases, Institut Louis MalardéLaboratory of Research On Emerging Viral Diseases, Institut Louis MalardéEnvironment and Infectious Risks Unit, Laboratory for Urgent Response to Biological Threats (CIBU), Institut Pasteur, Université Paris CitéEnvironment and Infectious Risks Unit, Laboratory for Urgent Response to Biological Threats (CIBU), Institut Pasteur, Université Paris CitéEmerging Diseases Epidemiology Unit, Institut Pasteur, Université Paris CitéLaboratory of Research On Emerging Viral Diseases, Institut Louis MalardéEmerging Diseases Epidemiology Unit, Institut Pasteur, Université Paris CitéAbstract Background French Polynesia (FP) comprises 75 inhabited islands scattered across five archipelagos. Between July and October 2021, the SARS-CoV-2 Delta variant triggered a much stronger second epidemic wave in FP than the original Wuhan strain, which was dominant from August 2020 to March 2021. Although previous seroprevalence surveys made it possible to determine the proportion of the population infected by SARS-CoV-2 on the two most populated islands (Tahiti and Moorea) after the first (20.6% in Tahiti and 9.4% in Moorea) and second (57.7% in Tahiti) epidemic waves, no data are available for more remote islands. We used blood samples and personal data collected before, during, and after the second wave from inhabitants of several islands within the five archipelagos to assess the prevalence of SARS-CoV-2 infections and identify associated factors. Methods Blood samples and personal data were collected between April and December 2021 as part of the MATAEA study, a cross-sectional survey conducted on a random sample of the adult population representative of the five FP archipelagos and stratified by age and gender. IgG antibodies targeting the SARS-CoV-2 nucleocapsid (N) protein were detected using a recombinant antigen-based microsphere immunoassay. Factors associated with anti-SARS-CoV-2-N seropositivity were identified using logistic regression models. Results Of 1,120 participants, 503 (44.9%) tested positive for anti-SARS-CoV-2-N antibodies, corresponding to a weighted prevalence of 56.8% for the FP population aged 18–69 years. The seroprevalence increased from 21.9% to 62.1% before and during/after the Delta wave. Of these infections, only 28.4% had been diagnosed by health professionals. The odds of being seropositive were lower in males, participants recruited before the Delta wave, those who had never been married, those with a diagnosed respiratory allergy, smokers, and those vaccinated against COVID-19. Conclusions Our results confirm the high impact of the Delta wave in FP. By the end of 2021, 56.8% of the FP population aged 18–69 years had been infected by SARS-CoV-2; the majority of these infections went undetected. Individuals with respiratory allergies were found to be less susceptible to SARS-CoV-2 infection.https://doi.org/10.1186/s12889-024-17869-4SARS-CoV-2COVID-19SeroprevalenceRisk factorGeneral populationFrench Polynesia |
| spellingShingle | Vincent Mendiboure Iotefa Teiti Maite Aubry Anita Teissier Tuterarii Paoaafaite Jessica Vanhomwegen Jean-Claude Manuguerra Arnaud Fontanet Van-Mai Cao-Lormeau Yoann Madec SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study BMC Public Health SARS-CoV-2 COVID-19 Seroprevalence Risk factor General population French Polynesia |
| title | SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study |
| title_full | SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study |
| title_fullStr | SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study |
| title_full_unstemmed | SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study |
| title_short | SARS-CoV-2 seroprevalence and associated factors of infection before and after the Delta wave in French Polynesia: a cross-sectional study |
| title_sort | sars cov 2 seroprevalence and associated factors of infection before and after the delta wave in french polynesia a cross sectional study |
| topic | SARS-CoV-2 COVID-19 Seroprevalence Risk factor General population French Polynesia |
| url | https://doi.org/10.1186/s12889-024-17869-4 |
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