A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer

A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer

Abstract Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential for the activation of key oncogenes in various cancers. However, the mechanism of action for most tumor-...

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Bibliographic Details
Main Authors: Yongheng Chen, Ying Ying, Maolin Wang, Canjie Ma, Min Jia, Liang Shi, Shilan Wang, Xiangyi Zheng, Wei Chen, Xing-sheng Shu
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05513-1

Internet

https://doi.org/10.1038/s41419-022-05513-1

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