Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy
Purpose: To assess the planned dose, in vivo dosimetry, acute skin toxicity, pain, and distress using Thermoplastic Elastomer (TPE) bolus for postmastectomy radiotherapy (PMRT). Material and methods: Thirty-two PMRT patients with TPE bolus (17 patients for 25 fractions, 15 patients for the first 20...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Breast |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977622001916 |
| _version_ | 1811289887478906880 |
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| author | Pan Gong Guyu Dai Xiaoyu Wu Xuetao Wang Li Xie Shuni Xu Renming Zhong |
| author_facet | Pan Gong Guyu Dai Xiaoyu Wu Xuetao Wang Li Xie Shuni Xu Renming Zhong |
| author_sort | Pan Gong |
| collection | DOAJ |
| description | Purpose: To assess the planned dose, in vivo dosimetry, acute skin toxicity, pain, and distress using Thermoplastic Elastomer (TPE) bolus for postmastectomy radiotherapy (PMRT). Material and methods: Thirty-two PMRT patients with TPE bolus (17 patients for 25 fractions, 15 patients for the first 20 fractions) were selected for the study. The acute skin toxicity, pain, and psychological distress were assessed from the first treatment week to the fourth week after the end of treatment. At the first treatment, the MOSFET was used in vivo dosimetry measurement. Results: In vivo dosimetry with the bolus, the dose deviation ranged from −6.22% to −1.56% for 5 points. The presence of grade 1 and 2 skin toxicity reached its peak (70.0% and 13.3%) in the sixth week. Two patients (6.6%) with 25 fractions bolus experienced moist desquamation in the fifth and seventh week, with pain score 2 and 3, and interruptions of 3 and 5 days, respectively. The incidence of pain score 1, 2, and 3 peaked in the fifth (33.3%), fourth (33.3%), and seventh (10.0%) week. No patients experienced grade 3 skin toxicity and severe pain. One patient had significant anxiety, and two patients had significant depression. Conclusion: The TPE bolus can accurately fit skin and improve the surface dose to more than 90%. Twenty fractions with TPE bolus had similar skin toxicity and pain to those without bolus and did not increase patients' distress and clinical workload, compared with the literature's data, which is an alternative to the 3D printing bolus for PMRT. |
| first_indexed | 2024-04-13T04:03:10Z |
| format | Article |
| id | doaj.art-4d2c61af66c145029c37cf0860728aee |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-04-13T04:03:10Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-4d2c61af66c145029c37cf0860728aee2022-12-22T03:03:25ZengElsevierBreast1532-30802022-12-0166317323Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapyPan Gong0Guyu Dai1Xiaoyu Wu2Xuetao Wang3Li Xie4Shuni Xu5Renming Zhong6Radiotherapy Physics and Technology Center, Cancer Center, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR ChinaRadiotherapy Physics and Technology Center, Cancer Center, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR ChinaDepartment of Respiratory Critical Care Medicine/Thoracic Surgery, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR ChinaRadiotherapy Physics and Technology Center, Cancer Center, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR ChinaDepartment of Radiotherapy/Department of Head and Neck Oncology, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR ChinaRadiotherapy Physics and Technology Center, Cancer Center, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR ChinaRadiotherapy Physics and Technology Center, Cancer Center, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, PR China; Corresponding author.Purpose: To assess the planned dose, in vivo dosimetry, acute skin toxicity, pain, and distress using Thermoplastic Elastomer (TPE) bolus for postmastectomy radiotherapy (PMRT). Material and methods: Thirty-two PMRT patients with TPE bolus (17 patients for 25 fractions, 15 patients for the first 20 fractions) were selected for the study. The acute skin toxicity, pain, and psychological distress were assessed from the first treatment week to the fourth week after the end of treatment. At the first treatment, the MOSFET was used in vivo dosimetry measurement. Results: In vivo dosimetry with the bolus, the dose deviation ranged from −6.22% to −1.56% for 5 points. The presence of grade 1 and 2 skin toxicity reached its peak (70.0% and 13.3%) in the sixth week. Two patients (6.6%) with 25 fractions bolus experienced moist desquamation in the fifth and seventh week, with pain score 2 and 3, and interruptions of 3 and 5 days, respectively. The incidence of pain score 1, 2, and 3 peaked in the fifth (33.3%), fourth (33.3%), and seventh (10.0%) week. No patients experienced grade 3 skin toxicity and severe pain. One patient had significant anxiety, and two patients had significant depression. Conclusion: The TPE bolus can accurately fit skin and improve the surface dose to more than 90%. Twenty fractions with TPE bolus had similar skin toxicity and pain to those without bolus and did not increase patients' distress and clinical workload, compared with the literature's data, which is an alternative to the 3D printing bolus for PMRT.http://www.sciencedirect.com/science/article/pii/S0960977622001916TPE bolusPostmastectomy radiotherapyIn vivo dosimetrySkin toxicityPain |
| spellingShingle | Pan Gong Guyu Dai Xiaoyu Wu Xuetao Wang Li Xie Shuni Xu Renming Zhong Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy Breast TPE bolus Postmastectomy radiotherapy In vivo dosimetry Skin toxicity Pain |
| title | Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy |
| title_full | Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy |
| title_fullStr | Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy |
| title_full_unstemmed | Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy |
| title_short | Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy |
| title_sort | application of thermoplastic elastomer tpe bolus in postmastectomy radiotherapy |
| topic | TPE bolus Postmastectomy radiotherapy In vivo dosimetry Skin toxicity Pain |
| url | http://www.sciencedirect.com/science/article/pii/S0960977622001916 |
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