CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response

CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response

Background: Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing enzymes and drug response (CYP2A6...

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Bibliographic Details
Main Authors: Chao Fang, Wen Ouyang, Youjie Zeng, Qi Pei, Yuhao Xia, Siwan Luo, Minghua Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
dexmedetomidine
pharmacogenomics
pharmacokinetic
pharmacodynamics
GABA A receptor
CYP2A6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.943200/full

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