Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan
Abstract Aims/Introduction Diabetes mellitus is reported as a risk factor for increased coronavirus disease 2019 (COVID‐19) severity and mortality, but there have been few reports from Japan. Associations between diabetes mellitus and COVID‐19 severity and mortality were investigated in a single Jap...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13784 |
| _version_ | 1818234709563408384 |
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| author | Yosuke Yakushiji Koka Motoyama Mayu Fukuda Hisako Takahashi Makiko Kimura Satoshi Tazoe Hiromi Iida Anna Tamai Takeshi Sakura Yoshihiro Isaka Mariko Fukumoto Keiko Yamagami Hidenori Nakagawa Michinori Shirano Masayuki Hosoi |
| author_facet | Yosuke Yakushiji Koka Motoyama Mayu Fukuda Hisako Takahashi Makiko Kimura Satoshi Tazoe Hiromi Iida Anna Tamai Takeshi Sakura Yoshihiro Isaka Mariko Fukumoto Keiko Yamagami Hidenori Nakagawa Michinori Shirano Masayuki Hosoi |
| author_sort | Yosuke Yakushiji |
| collection | DOAJ |
| description | Abstract Aims/Introduction Diabetes mellitus is reported as a risk factor for increased coronavirus disease 2019 (COVID‐19) severity and mortality, but there have been few reports from Japan. Associations between diabetes mellitus and COVID‐19 severity and mortality were investigated in a single Japanese hospital. Materials and Methods Patients aged ≥20 years admitted to Osaka City General Hospital for COVID‐19 treatment between April 2020 and March 2021 were included in this retrospective, observational study. Multivariable logistic regression analysis was carried out to examine whether diabetes mellitus contributes to COVID‐19‐related death and severity. Results Of the 262 patients included, 108 (41.2%) required invasive ventilation, and 34 (13.0%) died in hospital. The diabetes group (n = 92) was significantly older, more obese, had longer hospital stays, more severe illness and higher mortality than the non‐diabetes group (n = 170). On multivariable logistic regression analysis, age (odds ratio [OR] 1.054, 95% confidence interval [CI] 1.023–1.086), body mass index (OR 1.111, 95% CI 1.028–1.201), history of diabetes mellitus (OR 2.429, 95% CI 1.152–5.123), neutrophil count (OR 1.222, 95% CI 1.077–1.385), C‐reactive protein (OR 1.096, 95% CI 1.030–1.166) and Krebs von den Lungen‐6 (OR 1.002, 95% CI 1.000–1.003) were predictors for COVID‐19 severity (R2 = 0.468). Meanwhile, age (OR 1.104, 95% CI 1.037–1.175) and Krebs von den Lungen‐6 (OR 1.003, 95% CI 1.001–1.005) were predictors for COVID‐19‐related death (R2 = 0.475). Conclusions Diabetes mellitus was a definite risk factor for COVID‐19 severity in a single Japanese hospital treating moderately‐to‐severely ill patients. |
| first_indexed | 2024-12-12T11:42:23Z |
| format | Article |
| id | doaj.art-4d2cf7f5a015463eaf80af402ef24023 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-12T11:42:23Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-4d2cf7f5a015463eaf80af402ef240232022-12-22T00:25:31ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-07-011371277128510.1111/jdi.13784Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from JapanYosuke Yakushiji0Koka Motoyama1Mayu Fukuda2Hisako Takahashi3Makiko Kimura4Satoshi Tazoe5Hiromi Iida6Anna Tamai7Takeshi Sakura8Yoshihiro Isaka9Mariko Fukumoto10Keiko Yamagami11Hidenori Nakagawa12Michinori Shirano13Masayuki Hosoi14Department of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanDepartment of Infectious Disease Osaka City General Hospital Osaka JapanAbstract Aims/Introduction Diabetes mellitus is reported as a risk factor for increased coronavirus disease 2019 (COVID‐19) severity and mortality, but there have been few reports from Japan. Associations between diabetes mellitus and COVID‐19 severity and mortality were investigated in a single Japanese hospital. Materials and Methods Patients aged ≥20 years admitted to Osaka City General Hospital for COVID‐19 treatment between April 2020 and March 2021 were included in this retrospective, observational study. Multivariable logistic regression analysis was carried out to examine whether diabetes mellitus contributes to COVID‐19‐related death and severity. Results Of the 262 patients included, 108 (41.2%) required invasive ventilation, and 34 (13.0%) died in hospital. The diabetes group (n = 92) was significantly older, more obese, had longer hospital stays, more severe illness and higher mortality than the non‐diabetes group (n = 170). On multivariable logistic regression analysis, age (odds ratio [OR] 1.054, 95% confidence interval [CI] 1.023–1.086), body mass index (OR 1.111, 95% CI 1.028–1.201), history of diabetes mellitus (OR 2.429, 95% CI 1.152–5.123), neutrophil count (OR 1.222, 95% CI 1.077–1.385), C‐reactive protein (OR 1.096, 95% CI 1.030–1.166) and Krebs von den Lungen‐6 (OR 1.002, 95% CI 1.000–1.003) were predictors for COVID‐19 severity (R2 = 0.468). Meanwhile, age (OR 1.104, 95% CI 1.037–1.175) and Krebs von den Lungen‐6 (OR 1.003, 95% CI 1.001–1.005) were predictors for COVID‐19‐related death (R2 = 0.475). Conclusions Diabetes mellitus was a definite risk factor for COVID‐19 severity in a single Japanese hospital treating moderately‐to‐severely ill patients.https://doi.org/10.1111/jdi.13784COVID‐19Diabetes mellitusRetrospective study |
| spellingShingle | Yosuke Yakushiji Koka Motoyama Mayu Fukuda Hisako Takahashi Makiko Kimura Satoshi Tazoe Hiromi Iida Anna Tamai Takeshi Sakura Yoshihiro Isaka Mariko Fukumoto Keiko Yamagami Hidenori Nakagawa Michinori Shirano Masayuki Hosoi Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan Journal of Diabetes Investigation COVID‐19 Diabetes mellitus Retrospective study |
| title | Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan |
| title_full | Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan |
| title_fullStr | Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan |
| title_full_unstemmed | Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan |
| title_short | Impact of diabetes and Krebs von den Lungen‐6 on coronavirus disease 2019 severity: A single‐center study from Japan |
| title_sort | impact of diabetes and krebs von den lungen 6 on coronavirus disease 2019 severity a single center study from japan |
| topic | COVID‐19 Diabetes mellitus Retrospective study |
| url | https://doi.org/10.1111/jdi.13784 |
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