LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later
Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this alle...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/7/2165 |
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| author | Diana Betancor Alicia Gomez-Lopez Carlos Villalobos-Vilda Emilio Nuñez-Borque Sergio Fernández-Bravo Manuel De las Heras Gozalo Carlos Pastor-Vargas Vanesa Esteban Javier Cuesta-Herranz |
| author_facet | Diana Betancor Alicia Gomez-Lopez Carlos Villalobos-Vilda Emilio Nuñez-Borque Sergio Fernández-Bravo Manuel De las Heras Gozalo Carlos Pastor-Vargas Vanesa Esteban Javier Cuesta-Herranz |
| author_sort | Diana Betancor |
| collection | DOAJ |
| description | Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly <i>Rosaceae</i>/<i>Prunoideae</i> fruits and nuts followed by vegetables, <i>Rosacea</i>/<i>Pomoideae</i> fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to <i>Rosaceae</i>/<i>Prunoideae</i> fruits, two to <i>Rosaceae</i>/<i>Prunoideae</i> fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly <i>Rosaceae-Prunoideae</i> fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy. |
| first_indexed | 2024-03-10T10:06:27Z |
| format | Article |
| id | doaj.art-4d2f27ff56ac40d4a1eb7de4cc717164 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:06:27Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4d2f27ff56ac40d4a1eb7de4cc7171642023-11-22T01:30:06ZengMDPI AGNutrients2072-66432021-06-01137216510.3390/nu13072165LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years LaterDiana Betancor0Alicia Gomez-Lopez1Carlos Villalobos-Vilda2Emilio Nuñez-Borque3Sergio Fernández-Bravo4Manuel De las Heras Gozalo5Carlos Pastor-Vargas6Vanesa Esteban7Javier Cuesta-Herranz8Department of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainRETIC ARADyAL, Instituto de Salud Carlos III, 28029 Madrid, SpainDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainDepartment of Allergy, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, SpainIntroduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly <i>Rosaceae</i>/<i>Prunoideae</i> fruits and nuts followed by vegetables, <i>Rosacea</i>/<i>Pomoideae</i> fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to <i>Rosaceae</i>/<i>Prunoideae</i> fruits, two to <i>Rosaceae</i>/<i>Prunoideae</i> fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly <i>Rosaceae-Prunoideae</i> fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy.https://www.mdpi.com/2072-6643/13/7/2165nsLTPplant-food allergyPru p 3peachnut<i>Rosaceae</i> fruit |
| spellingShingle | Diana Betancor Alicia Gomez-Lopez Carlos Villalobos-Vilda Emilio Nuñez-Borque Sergio Fernández-Bravo Manuel De las Heras Gozalo Carlos Pastor-Vargas Vanesa Esteban Javier Cuesta-Herranz LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later Nutrients nsLTP plant-food allergy Pru p 3 peach nut <i>Rosaceae</i> fruit |
| title | LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later |
| title_full | LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later |
| title_fullStr | LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later |
| title_full_unstemmed | LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later |
| title_short | LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later |
| title_sort | ltp allergy follow up study development of allergy to new plant foods 10 years later |
| topic | nsLTP plant-food allergy Pru p 3 peach nut <i>Rosaceae</i> fruit |
| url | https://www.mdpi.com/2072-6643/13/7/2165 |
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