CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function
CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill mult...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2012-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/55/1/0012/ |
| _version_ | 1828823097429458944 |
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| author | Drahomíra Holmannová Martina Koláčková Kateřina Kondělková Pavel Kuneš Jan Krejsek Ctirad Andrýs |
| author_facet | Drahomíra Holmannová Martina Koláčková Kateřina Kondělková Pavel Kuneš Jan Krejsek Ctirad Andrýs |
| author_sort | Drahomíra Holmannová |
| collection | DOAJ |
| description | CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3‑dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL‑10 and TGF‑β synthesis. CD200/CD200R are required for maintaining self‑tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss. |
| first_indexed | 2024-12-12T13:28:30Z |
| format | Article |
| id | doaj.art-4d3071d89a9a415ea6ddfd96aa47496d |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-12T13:28:30Z |
| publishDate | 2012-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-4d3071d89a9a415ea6ddfd96aa47496d2022-12-22T00:23:07ZengKarolinum PressActa Medica1211-42861805-96942012-01-01551121710.14712/18059694.2015.68CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and FunctionDrahomíra Holmannová0Martina Koláčková1Kateřina Kondělková2Pavel Kuneš3Jan Krejsek4Ctirad Andrýs5Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Clinical Immunology and AllergologyCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Clinical Immunology and AllergologyCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Clinical Immunology and AllergologyCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Cardiac SurgeryCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Clinical Immunology and AllergologyCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Clinical Immunology and AllergologyCD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3‑dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL‑10 and TGF‑β synthesis. CD200/CD200R are required for maintaining self‑tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.https://actamedica.lfhk.cuni.cz/55/1/0012/CD200CD200RInhibition mechanismsInflammationIDO |
| spellingShingle | Drahomíra Holmannová Martina Koláčková Kateřina Kondělková Pavel Kuneš Jan Krejsek Ctirad Andrýs CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function Acta Medica CD200 CD200R Inhibition mechanisms Inflammation IDO |
| title | CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function |
| title_full | CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function |
| title_fullStr | CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function |
| title_full_unstemmed | CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function |
| title_short | CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function |
| title_sort | cd200 cd200r paired potent inhibitory molecules regulating immune and inflammatory responses part i cd200 cd200r structure activation and function |
| topic | CD200 CD200R Inhibition mechanisms Inflammation IDO |
| url | https://actamedica.lfhk.cuni.cz/55/1/0012/ |
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