Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

Abstract Background Disturbances in coronary microcirculatory function, such as the endothelial glycocalyx, are early hallmarks in the development of obesity and insulin resistance. Accordingly, in the present study myocardial microcirculatory perfusion during rest and stress was assessed following...

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Bibliographic Details
Main Authors: Judith van Haare, M. Eline Kooi, Jurgen W. G. E. van Teeffelen, Hans Vink, Jos Slenter, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn, Mark J. Post, Marc van Bilsen
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Cardiovascular Diabetology
Subjects:
Obesity
Endothelial dysfunction
Myocardial perfusion
Cardiac function
Glycocalyx
Metformin
Online Access:http://link.springer.com/article/10.1186/s12933-017-0525-7

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