Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery
Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work perf...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/10/2398 |
| _version_ | 1827720151470964736 |
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| author | Youri Cortat Fabio Zobi |
| author_facet | Youri Cortat Fabio Zobi |
| author_sort | Youri Cortat |
| collection | DOAJ |
| description | Coordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in the field of coordination derivatives of AAs synthesized for medical purposes by discussing the corresponding publications and emphasizing the most promising compounds discovered so far. The resulting overview highlights the efficiency of AAs and their metallic species, as well as the potential still lying in this research area. |
| first_indexed | 2024-03-10T20:58:35Z |
| format | Article |
| id | doaj.art-4d31677c4e8a4c30b34a9fd88ebb9eca |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:58:35Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4d31677c4e8a4c30b34a9fd88ebb9eca2023-11-19T17:43:58ZengMDPI AGPharmaceutics1999-49232023-09-011510239810.3390/pharmaceutics15102398Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug DiscoveryYouri Cortat0Fabio Zobi1Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, SwitzerlandDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, SwitzerlandCoordination compounds featuring one or more antifungal azole (AA) ligands constitute an interesting family of candidate molecules, given their medicinal polyvalence and the viability of drug complexation as a strategy to improve and repurpose available medications. This review reports the work performed in the field of coordination derivatives of AAs synthesized for medical purposes by discussing the corresponding publications and emphasizing the most promising compounds discovered so far. The resulting overview highlights the efficiency of AAs and their metallic species, as well as the potential still lying in this research area.https://www.mdpi.com/1999-4923/15/10/2398repurposingantifungalazolemetalcomplexesmiconazole |
| spellingShingle | Youri Cortat Fabio Zobi Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery Pharmaceutics repurposing antifungal azole metal complexes miconazole |
| title | Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery |
| title_full | Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery |
| title_fullStr | Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery |
| title_full_unstemmed | Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery |
| title_short | Resurgence and Repurposing of Antifungal Azoles by Transition Metal Coordination for Drug Discovery |
| title_sort | resurgence and repurposing of antifungal azoles by transition metal coordination for drug discovery |
| topic | repurposing antifungal azole metal complexes miconazole |
| url | https://www.mdpi.com/1999-4923/15/10/2398 |
| work_keys_str_mv | AT youricortat resurgenceandrepurposingofantifungalazolesbytransitionmetalcoordinationfordrugdiscovery AT fabiozobi resurgenceandrepurposingofantifungalazolesbytransitionmetalcoordinationfordrugdiscovery |