Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (L...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2019-06-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/902 |
| _version_ | 1797875165451780096 |
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| author | A. V. Kamaev O. V. Trusova U. A. Butyrina I. V. Makarova |
| author_facet | A. V. Kamaev O. V. Trusova U. A. Butyrina I. V. Makarova |
| author_sort | A. V. Kamaev |
| collection | DOAJ |
| description | Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication. |
| first_indexed | 2024-04-10T01:43:18Z |
| format | Article |
| id | doaj.art-4d3207d328da43ee83a25c9fd721b390 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:43:18Z |
| publishDate | 2019-06-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-4d3207d328da43ee83a25c9fd721b3902023-03-13T09:12:47ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282019-06-0164310911610.21508/1027-4065-2019-64-3-109-117748Improvement of therapy efficacy in children with atopic dermatitis due to emollient complexA. V. Kamaev0O. V. Trusova1U. A. Butyrina2I. V. Makarova3ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава РоссииФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава РоссииДетское поликлиническое отделение №60 Городской поликлиники №91ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава РоссииActive studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication.https://www.ped-perinatology.ru/jour/article/view/902детиатопический дерматитэмолиентыэффективность лечения |
| spellingShingle | A. V. Kamaev O. V. Trusova U. A. Butyrina I. V. Makarova Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex Rossijskij Vestnik Perinatologii i Pediatrii дети атопический дерматит эмолиенты эффективность лечения |
| title | Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex |
| title_full | Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex |
| title_fullStr | Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex |
| title_full_unstemmed | Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex |
| title_short | Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex |
| title_sort | improvement of therapy efficacy in children with atopic dermatitis due to emollient complex |
| topic | дети атопический дерматит эмолиенты эффективность лечения |
| url | https://www.ped-perinatology.ru/jour/article/view/902 |
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