Structural Biology of Bacterial RNA Polymerase
Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural infor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Biomolecules |
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| Online Access: | http://www.mdpi.com/2218-273X/5/2/848 |
| _version_ | 1811303673045712896 |
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| author | Katsuhiko S. Murakami |
| author_facet | Katsuhiko S. Murakami |
| author_sort | Katsuhiko S. Murakami |
| collection | DOAJ |
| description | Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterial RNAP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription. |
| first_indexed | 2024-04-13T07:52:19Z |
| format | Article |
| id | doaj.art-4d32257079ae4653b08ac4df498c1bfb |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-04-13T07:52:19Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-4d32257079ae4653b08ac4df498c1bfb2022-12-22T02:55:30ZengMDPI AGBiomolecules2218-273X2015-05-015284886410.3390/biom5020848biom5020848Structural Biology of Bacterial RNA PolymeraseKatsuhiko S. Murakami0Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USASince its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterial RNAP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription.http://www.mdpi.com/2218-273X/5/2/848bacterial RNA polymerasetranscriptioncore enzymeholoenzymeσ factortranscription factoranti-σ factorX-ray crystallographyNMRinhibitor antibiotic |
| spellingShingle | Katsuhiko S. Murakami Structural Biology of Bacterial RNA Polymerase Biomolecules bacterial RNA polymerase transcription core enzyme holoenzyme σ factor transcription factor anti-σ factor X-ray crystallography NMR inhibitor antibiotic |
| title | Structural Biology of Bacterial RNA Polymerase |
| title_full | Structural Biology of Bacterial RNA Polymerase |
| title_fullStr | Structural Biology of Bacterial RNA Polymerase |
| title_full_unstemmed | Structural Biology of Bacterial RNA Polymerase |
| title_short | Structural Biology of Bacterial RNA Polymerase |
| title_sort | structural biology of bacterial rna polymerase |
| topic | bacterial RNA polymerase transcription core enzyme holoenzyme σ factor transcription factor anti-σ factor X-ray crystallography NMR inhibitor antibiotic |
| url | http://www.mdpi.com/2218-273X/5/2/848 |
| work_keys_str_mv | AT katsuhikosmurakami structuralbiologyofbacterialrnapolymerase |