Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19
Active hydrogen inhalation (H(H2O)m) has powerful antioxidant and antiapoptotic effects. In recent years, it has been used in a number of experimental and clinical studies.Aim. To study the safety and effectiveness of inhalation of the “active form of hydrogen” (AFV;(H(H2O)m)) in the rehabilitation...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2021-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2986 |
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| author | L. V. Shogenova Thi Tuet Truong N. O. Kryukova K. A. Yusupkhodzhaeva D. D. Pozdnyakova T. G. Kim A. V. Chernyak Е. N. Kalmanova O. S. Medvedev T. A. Kuropatkina S. D. Varfolomeev A. M. Ryabokon O. А. Svitich M. P. Kostinov Ibaraki Kunio Maehara Hiroki A. G. Chuchalin |
| author_facet | L. V. Shogenova Thi Tuet Truong N. O. Kryukova K. A. Yusupkhodzhaeva D. D. Pozdnyakova T. G. Kim A. V. Chernyak Е. N. Kalmanova O. S. Medvedev T. A. Kuropatkina S. D. Varfolomeev A. M. Ryabokon O. А. Svitich M. P. Kostinov Ibaraki Kunio Maehara Hiroki A. G. Chuchalin |
| author_sort | L. V. Shogenova |
| collection | DOAJ |
| description | Active hydrogen inhalation (H(H2O)m) has powerful antioxidant and antiapoptotic effects. In recent years, it has been used in a number of experimental and clinical studies.Aim. To study the safety and effectiveness of inhalation of the “active form of hydrogen” (AFV;(H(H2O)m)) in the rehabilitation program of coronavirus disease 2019 (COVID-19) survivors during the recovery period.Material and methods. This randomized controlled parallel prospective study included 60 COVID-19 survivors with post-COVID-19 syndrome (ICD-10: U09.9) during the recovery period, with clinical manifestations of chronic fatigue syndrome (CFS), who received standard therapy in accordance with the management protocol of patients with CFS (ICD-10: G93.3): physiotherapy and medication therapy with drugs containing magnesium, B vitamins and L-carnitine. The patients were divided into 2 groups. The experimental group (n=30) included patients who received hydrogen inhalation for 90 minutes every day during 10 days (SUISONIA hydrogen inhalation device, Japan). The control group (n=30) consisted of patients who received standard therapy. In both groups, patients were comparable in sex and mean age: in the experimental group — 53 (22; 70) years, in the control group — 51 (25; 70) years. Biological markers of systemic inflammation, oxygen transport, lactate metabolism, intrapulmonary shunting, 6-minute walk test, and vascular endothelial function were determined in all patients on the 1st and 10th days of follow-up.Results. In the experimental group, a decrease in following parameters was revealed: stiffness index (SI), from 8,8±1,8 to 6,8±1,5 (p<0,0001); ALT, from 24,0±12,7 to 20,22±10,61 U/L (p<0,001); venous blood lactate, from 2,5±0,8 to 1,5±1,0 mmol/L (p<0,001); capillary blood lactate, from 2,9±0,8 to 2,0±0,8 mmol/L (p<0,0001); estimated pulmonary shunt fraction (Qs/Qt, Berggren equation, 1942) from 8,98±5,7 to 5,34±3,2 (p<0,01); white blood cells, from 6,64±1,57 to 5,92±1,32 109/L. In addition, we revealed an increase in the refractive index (RI) from 46,67±13,26% to 63,32±13,44% (p<0,0001), minimum blood oxygen saturation (SpO2) from 92,25±2,9 to 94,25±1, 56% (p<0,05), direct bilirubin from 2,99±1,41 to 3,39±1,34 pmol/L (p<0,01), partial oxygen tension (PvO2) from 26,9±5,0 to 34,8±5,6 mm Hg (p<0,0001), venous oxygen saturation (SvO2) from 51,8±020,6 to 61,1±018,1% (p<0,05), partial capillary oxygen tension (PcO2) from 48,7±15,4 to 63,8±21,2 mm Hg (p<0,01), capillary oxygen saturation (ScO2) from 82,2±4,2 to 86,2±4,8% (p<0,01), distance in 6 minute walk test from 429±45,0 to 569±60 m.Conclusion. Inhalation therapy with H(H2O)m in the rehabilitation program of COVID-19 survivors during the recovery period is a safe and highly effective method. Manifestations of silent hypoxemia and endothelial dysfunction decreased, while exercise tolerance increased. As for laboratory tests, a decrease in the white blood cell count, estimated pulmonary shunt fraction and lactate content parameters was revealed. |
| first_indexed | 2024-04-10T03:33:56Z |
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| id | doaj.art-4d32b81b25b44bfab0e7b374a7b08d65 |
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| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:35:20Z |
| publishDate | 2021-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
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| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-4d32b81b25b44bfab0e7b374a7b08d652024-10-17T12:21:41Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-10-0120610.15829/1728-8800-2021-29862336Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19L. V. Shogenova0Thi Tuet Truong1N. O. Kryukova2K. A. Yusupkhodzhaeva3D. D. Pozdnyakova4T. G. Kim5A. V. Chernyak6Е. N. Kalmanova7O. S. Medvedev8T. A. Kuropatkina9S. D. Varfolomeev10A. M. Ryabokon11O. А. Svitich12M. P. Kostinov13Ibaraki Kunio14Maehara Hiroki15A. G. Chuchalin16Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical University; D.D. Pletnev City Clinical HospitalPulmonology Research Institute, Federal Medical and Biological Agency of RussiaPirogov Russian National Research Medical University; D.D. Pletnev City Clinical HospitalLomonosov Moscow State UniversityLomonosov Moscow State UniversityInstitute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intellegence, Lomonosov Moscow State University; N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Lomonosov Moscow State UniversityN.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Lomonosov Moscow State UniversityI.I. Mechnikov Scientific Research Institute of Vaccines and SerumsI.I. Mechnikov Scientific Research Institute of Vaccines and SerumsUniversity of the RyukyusUniversity of the Ryukyus HospitalPirogov Russian National Research Medical UniversityActive hydrogen inhalation (H(H2O)m) has powerful antioxidant and antiapoptotic effects. In recent years, it has been used in a number of experimental and clinical studies.Aim. To study the safety and effectiveness of inhalation of the “active form of hydrogen” (AFV;(H(H2O)m)) in the rehabilitation program of coronavirus disease 2019 (COVID-19) survivors during the recovery period.Material and methods. This randomized controlled parallel prospective study included 60 COVID-19 survivors with post-COVID-19 syndrome (ICD-10: U09.9) during the recovery period, with clinical manifestations of chronic fatigue syndrome (CFS), who received standard therapy in accordance with the management protocol of patients with CFS (ICD-10: G93.3): physiotherapy and medication therapy with drugs containing magnesium, B vitamins and L-carnitine. The patients were divided into 2 groups. The experimental group (n=30) included patients who received hydrogen inhalation for 90 minutes every day during 10 days (SUISONIA hydrogen inhalation device, Japan). The control group (n=30) consisted of patients who received standard therapy. In both groups, patients were comparable in sex and mean age: in the experimental group — 53 (22; 70) years, in the control group — 51 (25; 70) years. Biological markers of systemic inflammation, oxygen transport, lactate metabolism, intrapulmonary shunting, 6-minute walk test, and vascular endothelial function were determined in all patients on the 1st and 10th days of follow-up.Results. In the experimental group, a decrease in following parameters was revealed: stiffness index (SI), from 8,8±1,8 to 6,8±1,5 (p<0,0001); ALT, from 24,0±12,7 to 20,22±10,61 U/L (p<0,001); venous blood lactate, from 2,5±0,8 to 1,5±1,0 mmol/L (p<0,001); capillary blood lactate, from 2,9±0,8 to 2,0±0,8 mmol/L (p<0,0001); estimated pulmonary shunt fraction (Qs/Qt, Berggren equation, 1942) from 8,98±5,7 to 5,34±3,2 (p<0,01); white blood cells, from 6,64±1,57 to 5,92±1,32 109/L. In addition, we revealed an increase in the refractive index (RI) from 46,67±13,26% to 63,32±13,44% (p<0,0001), minimum blood oxygen saturation (SpO2) from 92,25±2,9 to 94,25±1, 56% (p<0,05), direct bilirubin from 2,99±1,41 to 3,39±1,34 pmol/L (p<0,01), partial oxygen tension (PvO2) from 26,9±5,0 to 34,8±5,6 mm Hg (p<0,0001), venous oxygen saturation (SvO2) from 51,8±020,6 to 61,1±018,1% (p<0,05), partial capillary oxygen tension (PcO2) from 48,7±15,4 to 63,8±21,2 mm Hg (p<0,01), capillary oxygen saturation (ScO2) from 82,2±4,2 to 86,2±4,8% (p<0,01), distance in 6 minute walk test from 429±45,0 to 569±60 m.Conclusion. Inhalation therapy with H(H2O)m in the rehabilitation program of COVID-19 survivors during the recovery period is a safe and highly effective method. Manifestations of silent hypoxemia and endothelial dysfunction decreased, while exercise tolerance increased. As for laboratory tests, a decrease in the white blood cell count, estimated pulmonary shunt fraction and lactate content parameters was revealed.https://cardiovascular.elpub.ru/jour/article/view/2986hydrogenactive hydrogen (h(h2o)m)covid-19post-covid-19 syndromerehabilitationlactateoxygen transportsilent hypoxemia |
| spellingShingle | L. V. Shogenova Thi Tuet Truong N. O. Kryukova K. A. Yusupkhodzhaeva D. D. Pozdnyakova T. G. Kim A. V. Chernyak Е. N. Kalmanova O. S. Medvedev T. A. Kuropatkina S. D. Varfolomeev A. M. Ryabokon O. А. Svitich M. P. Kostinov Ibaraki Kunio Maehara Hiroki A. G. Chuchalin Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 Кардиоваскулярная терапия и профилактика hydrogen active hydrogen (h(h2o)m) covid-19 post-covid-19 syndrome rehabilitation lactate oxygen transport silent hypoxemia |
| title | Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 |
| title_full | Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 |
| title_fullStr | Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 |
| title_full_unstemmed | Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 |
| title_short | Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 |
| title_sort | hydrogen inhalation in rehabilitation program of the medical staff recovered from covid 19 |
| topic | hydrogen active hydrogen (h(h2o)m) covid-19 post-covid-19 syndrome rehabilitation lactate oxygen transport silent hypoxemia |
| url | https://cardiovascular.elpub.ru/jour/article/view/2986 |
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