Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery
Despite the recent advances in drug development, the majority of novel therapeutics have not been successfully translated into clinical applications. One of the major factors hindering their clinical translation is the lack of a safe, non-immunogenic delivery system with high target specificity upon...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/10/2191 |
| _version_ | 1797552278251503616 |
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| author | Xuan T. T. Dang Jayasinghe Migara Kavishka Daniel Xin Zhang Marco Pirisinu Minh T. N. Le |
| author_facet | Xuan T. T. Dang Jayasinghe Migara Kavishka Daniel Xin Zhang Marco Pirisinu Minh T. N. Le |
| author_sort | Xuan T. T. Dang |
| collection | DOAJ |
| description | Despite the recent advances in drug development, the majority of novel therapeutics have not been successfully translated into clinical applications. One of the major factors hindering their clinical translation is the lack of a safe, non-immunogenic delivery system with high target specificity upon systemic administration. In this respect, extracellular vesicles (EVs), as natural carriers of bioactive cargo, have emerged as a promising solution and can be further modified to improve their therapeutic efficacy. In this review, we provide an overview of the biogenesis pathways, biochemical features, and isolation methods of EVs with an emphasis on their many intrinsic properties that make them desirable as drug carriers. We then describe in detail the current advances in EV therapeutics, focusing on how EVs can be engineered to achieve improved target specificity, better circulation kinetics, and efficient encapsulation of therapeutic payloads. We also identify the challenges and obstacles ahead for clinical translation and provide an outlook on the future perspective of EV-based therapeutics. |
| first_indexed | 2024-03-10T15:58:43Z |
| format | Article |
| id | doaj.art-4d33726a87f140b0902b0286ff028f6d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:58:43Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4d33726a87f140b0902b0286ff028f6d2023-11-20T15:27:17ZengMDPI AGCells2073-44092020-09-01910219110.3390/cells9102191Extracellular Vesicles as an Efficient and Versatile System for Drug DeliveryXuan T. T. Dang0Jayasinghe Migara Kavishka1Daniel Xin Zhang2Marco Pirisinu3Minh T. N. Le4Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong KongDepartment of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong KongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDespite the recent advances in drug development, the majority of novel therapeutics have not been successfully translated into clinical applications. One of the major factors hindering their clinical translation is the lack of a safe, non-immunogenic delivery system with high target specificity upon systemic administration. In this respect, extracellular vesicles (EVs), as natural carriers of bioactive cargo, have emerged as a promising solution and can be further modified to improve their therapeutic efficacy. In this review, we provide an overview of the biogenesis pathways, biochemical features, and isolation methods of EVs with an emphasis on their many intrinsic properties that make them desirable as drug carriers. We then describe in detail the current advances in EV therapeutics, focusing on how EVs can be engineered to achieve improved target specificity, better circulation kinetics, and efficient encapsulation of therapeutic payloads. We also identify the challenges and obstacles ahead for clinical translation and provide an outlook on the future perspective of EV-based therapeutics.https://www.mdpi.com/2073-4409/9/10/2191extracellular vesiclesdrug deliverytherapeuticclinicaltranslation |
| spellingShingle | Xuan T. T. Dang Jayasinghe Migara Kavishka Daniel Xin Zhang Marco Pirisinu Minh T. N. Le Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery Cells extracellular vesicles drug delivery therapeutic clinical translation |
| title | Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery |
| title_full | Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery |
| title_fullStr | Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery |
| title_full_unstemmed | Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery |
| title_short | Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery |
| title_sort | extracellular vesicles as an efficient and versatile system for drug delivery |
| topic | extracellular vesicles drug delivery therapeutic clinical translation |
| url | https://www.mdpi.com/2073-4409/9/10/2191 |
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