Detection of Spinal Muscular Atrophy Patients Using Dried Saliva Spots

Detection of Spinal Muscular Atrophy Patients Using Dried Saliva Spots

Spinal muscular atrophy (SMA) is a lower motor neuron disease, once considered incurable. The main symptoms are muscle weakness and muscular atrophy. More than 90% of cases of SMA are caused by homozygous deletion of survival motor neuron 1 (<i>SMN1</i>). Emerging treatments, such as spl...

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Bibliographic Details
Main Authors: Yogik Onky Silvana Wijaya, Hisahide Nishio, Emma Tabe Eko Niba, Kentaro Okamoto, Haruo Shintaku, Yasuhiro Takeshima, Toshio Saito, Masakazu Shinohara, Hiroyuki Awano
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Genes
Subjects:
dried saliva spot
spinal muscular atrophy
<i>SMN1</i>
modified competitive oligonucleotide priming-polymerase chain reaction
melting peak analysis
nested PCR
Online Access:https://www.mdpi.com/2073-4425/12/10/1621

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