Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Abstract Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD). The expression of α-klotho, an antiaging protein, declines with age, incre...

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Bibliographic Details
Main Authors: Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05851-8

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