Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?
Introduction Cisplatin is an antineoplastic agent, which is thought to act on tissues with increased levels of reactive oxygen species and decreased levels of antioxidants. Pycnogenol is a potent antioxidant that is used in medical conditions caused by oxidative stress. The aim of our study is to de...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2019-12-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Can-pycnogenol-prevent-cisplatin-induced-damage-in-uterus-and-ovaries-,109151,0,2.html |
| _version_ | 1827620358750994432 |
|---|---|
| author | Can Turkler Tunay Kiremitli Taylan Onat Engin Yildirim Gulce N. Yazici Renad Mammadov Mukadder Sunar |
| author_facet | Can Turkler Tunay Kiremitli Taylan Onat Engin Yildirim Gulce N. Yazici Renad Mammadov Mukadder Sunar |
| author_sort | Can Turkler |
| collection | DOAJ |
| description | Introduction
Cisplatin is an antineoplastic agent, which is thought to act on tissues with increased levels of reactive oxygen species and decreased levels of antioxidants. Pycnogenol is a potent antioxidant that is used in medical conditions caused by oxidative stress. The aim of our study is to demonstrate the effects of pycnogenol on cisplatin-induced uterine and ovarian damage in rats.
Material and methods
Wistar albino female rats were randomly divided into 3 groups before the experiment as follows: a 2.5 mg/kg cisplatin group (CG; n = 10), a 40 mg/kg pycnogenol + 2.5 mg/kg cisplatin group (PCG; n = 10), and a healthy control group (HG; n = 10). Then, the ovaries and uteri of the rats were examined to determine malondialdehyde (MDA), total glutathione (tGSH) and superoxide dismutase (SOD) biochemical levels and the histopathological findings.
Results
Our study demonstrated that, in uterine and ovarian tissues of rats administered with cisplatin, there was a decrease in the levels of tGSH and SOD, while MDA was increased; however, it was observed that these ratios were reversed in the PCG group (p < 0.05). The number of follicles in the ovarian tissues was examined in all 3 groups. When the CG group was compared with the other two groups, the number of primordial, developing and atretic follicles was low, but there was no difference in the corpus luteum count.
Conclusions
Pycnogenol pretreatment alleviates cisplatin-induced uterine and ovarian injury in rats because of its antioxidative effect. |
| first_indexed | 2024-03-09T10:46:20Z |
| format | Article |
| id | doaj.art-4d399c47566f4bdeb7e9218780ce7388 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:20Z |
| publishDate | 2019-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-4d399c47566f4bdeb7e9218780ce73882023-12-01T10:00:43ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512019-12-011851364137110.5114/aoms.2019.90414109151Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?Can Turkler0Tunay Kiremitli1Taylan Onat2Engin Yildirim3Gulce N. Yazici4Renad Mammadov5Mukadder Sunar6Department of Gynecology and Obstetrics, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, TurkeyDepartment of Gynecology and Obstetrics, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, TurkeyDepartment of Gynecology and Obstetrics, Faculty of Medicine, Bozok University, Yozgat, TurkeyDepartment of Gynecology and Obstetrics, Faculty of Medicine, Hitit University, Corum, TurkeyDepartment of Histology and Embryology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, TurkeyDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, TurkeyDepartment of Anatomy, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, TurkeyIntroduction Cisplatin is an antineoplastic agent, which is thought to act on tissues with increased levels of reactive oxygen species and decreased levels of antioxidants. Pycnogenol is a potent antioxidant that is used in medical conditions caused by oxidative stress. The aim of our study is to demonstrate the effects of pycnogenol on cisplatin-induced uterine and ovarian damage in rats. Material and methods Wistar albino female rats were randomly divided into 3 groups before the experiment as follows: a 2.5 mg/kg cisplatin group (CG; n = 10), a 40 mg/kg pycnogenol + 2.5 mg/kg cisplatin group (PCG; n = 10), and a healthy control group (HG; n = 10). Then, the ovaries and uteri of the rats were examined to determine malondialdehyde (MDA), total glutathione (tGSH) and superoxide dismutase (SOD) biochemical levels and the histopathological findings. Results Our study demonstrated that, in uterine and ovarian tissues of rats administered with cisplatin, there was a decrease in the levels of tGSH and SOD, while MDA was increased; however, it was observed that these ratios were reversed in the PCG group (p < 0.05). The number of follicles in the ovarian tissues was examined in all 3 groups. When the CG group was compared with the other two groups, the number of primordial, developing and atretic follicles was low, but there was no difference in the corpus luteum count. Conclusions Pycnogenol pretreatment alleviates cisplatin-induced uterine and ovarian injury in rats because of its antioxidative effect.https://www.archivesofmedicalscience.com/Can-pycnogenol-prevent-cisplatin-induced-damage-in-uterus-and-ovaries-,109151,0,2.htmlcisplatinovaryoxidative stresspycnogenolratuterus |
| spellingShingle | Can Turkler Tunay Kiremitli Taylan Onat Engin Yildirim Gulce N. Yazici Renad Mammadov Mukadder Sunar Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? Archives of Medical Science cisplatin ovary oxidative stress pycnogenol rat uterus |
| title | Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? |
| title_full | Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? |
| title_fullStr | Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? |
| title_full_unstemmed | Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? |
| title_short | Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? |
| title_sort | can pycnogenol prevent cisplatin induced damage in uterus and ovaries |
| topic | cisplatin ovary oxidative stress pycnogenol rat uterus |
| url | https://www.archivesofmedicalscience.com/Can-pycnogenol-prevent-cisplatin-induced-damage-in-uterus-and-ovaries-,109151,0,2.html |
| work_keys_str_mv | AT canturkler canpycnogenolpreventcisplatininduceddamageinuterusandovaries AT tunaykiremitli canpycnogenolpreventcisplatininduceddamageinuterusandovaries AT taylanonat canpycnogenolpreventcisplatininduceddamageinuterusandovaries AT enginyildirim canpycnogenolpreventcisplatininduceddamageinuterusandovaries AT gulcenyazici canpycnogenolpreventcisplatininduceddamageinuterusandovaries AT renadmammadov canpycnogenolpreventcisplatininduceddamageinuterusandovaries AT mukaddersunar canpycnogenolpreventcisplatininduceddamageinuterusandovaries |