Approach to Pregnancy in Patients With Lupus Nephritis
Active lupus nephritis (LN) in pregnancy is strongly associated with poor maternal and fetal outcomes and, therefore, has implications on the planning, timing, and management. Prepregnancy evaluation is essential for all LN patients with childbearing potential to ensure pregnancies proceed in a safe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
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| Series: | Kidney Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059523001425 |
| _version_ | 1797653884592717824 |
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| author | Benjamin Tan Paolo Nikolai So Anoushka Krishnan Sol Carriazo Josélyn Reyes Bahamonde Tanuj Moses Lamech Mohamed Hassanein Edgar Lerma Nasim Wiegley |
| author_facet | Benjamin Tan Paolo Nikolai So Anoushka Krishnan Sol Carriazo Josélyn Reyes Bahamonde Tanuj Moses Lamech Mohamed Hassanein Edgar Lerma Nasim Wiegley |
| author_sort | Benjamin Tan |
| collection | DOAJ |
| description | Active lupus nephritis (LN) in pregnancy is strongly associated with poor maternal and fetal outcomes and, therefore, has implications on the planning, timing, and management. Prepregnancy evaluation is essential for all LN patients with childbearing potential to ensure pregnancies proceed in a safe and timely manner. Both maternal and fetal risks are communicated to patient during the evaluation. Stratification into different risk profile groups is then made based on disease activity and organ impairment severity. Patients with LN are generally divided into 3 main groups. Patients with LN who become pregnant receive treatments that are nonteratogenic and optimal for fetal and maternal outcomes. Throughout the pregnancy period, these patients are monitored closely under surveillance by a multidisciplinary team of clinicians. The management of patients with LN in pregnancy can be challenging both diagnostically (distinguishing LN from pre-eclampsia and determining the role and timing of kidney biopsy) and therapeutically (LN flares during pregnancy and managing a newly diagnosed LN during pregnancy). |
| first_indexed | 2024-03-11T16:51:15Z |
| format | Article |
| id | doaj.art-4d3ad550e63c4452b115c15c33235c46 |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-03-11T16:51:15Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-4d3ad550e63c4452b115c15c33235c462023-10-21T04:23:13ZengElsevierKidney Medicine2590-05952023-11-01511100724Approach to Pregnancy in Patients With Lupus NephritisBenjamin Tan0Paolo Nikolai So1Anoushka Krishnan2Sol Carriazo3Josélyn Reyes Bahamonde4Tanuj Moses Lamech5Mohamed Hassanein6Edgar Lerma7Nasim Wiegley8Nephrology Unit, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia; Address for Correspondence: Benjamin Tan, Nephrology Unit, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia.Private Practice, Manila, PhilippinesRoyal Perth Hospital, Perth, AustraliaDepartment of Nephrology and Hypertension Department, Fundacion Jimenez Diaz Hospital, Madrid, SpainDepartment of Nephrology, St Luke’s University Health Network, PAInstitute of Nephrology, Madras Medical College, IndiaDivision of Nephrology and Hypertension, University of Mississippi Medical Center, Jackson, MISection of Nephrology, University of Illinois at Chicago, Chicago, ILDivision of Nephrology, University of California Davis School of Medicine, Sacramento, CAActive lupus nephritis (LN) in pregnancy is strongly associated with poor maternal and fetal outcomes and, therefore, has implications on the planning, timing, and management. Prepregnancy evaluation is essential for all LN patients with childbearing potential to ensure pregnancies proceed in a safe and timely manner. Both maternal and fetal risks are communicated to patient during the evaluation. Stratification into different risk profile groups is then made based on disease activity and organ impairment severity. Patients with LN are generally divided into 3 main groups. Patients with LN who become pregnant receive treatments that are nonteratogenic and optimal for fetal and maternal outcomes. Throughout the pregnancy period, these patients are monitored closely under surveillance by a multidisciplinary team of clinicians. The management of patients with LN in pregnancy can be challenging both diagnostically (distinguishing LN from pre-eclampsia and determining the role and timing of kidney biopsy) and therapeutically (LN flares during pregnancy and managing a newly diagnosed LN during pregnancy).http://www.sciencedirect.com/science/article/pii/S2590059523001425Lupus nephritispregnancyevaluationgroupsmaternalfetal |
| spellingShingle | Benjamin Tan Paolo Nikolai So Anoushka Krishnan Sol Carriazo Josélyn Reyes Bahamonde Tanuj Moses Lamech Mohamed Hassanein Edgar Lerma Nasim Wiegley Approach to Pregnancy in Patients With Lupus Nephritis Kidney Medicine Lupus nephritis pregnancy evaluation groups maternal fetal |
| title | Approach to Pregnancy in Patients With Lupus Nephritis |
| title_full | Approach to Pregnancy in Patients With Lupus Nephritis |
| title_fullStr | Approach to Pregnancy in Patients With Lupus Nephritis |
| title_full_unstemmed | Approach to Pregnancy in Patients With Lupus Nephritis |
| title_short | Approach to Pregnancy in Patients With Lupus Nephritis |
| title_sort | approach to pregnancy in patients with lupus nephritis |
| topic | Lupus nephritis pregnancy evaluation groups maternal fetal |
| url | http://www.sciencedirect.com/science/article/pii/S2590059523001425 |
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