To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase
Organic selenocyanates (RSeCN) are among the most reactive and biologically active Se species, often exhibiting a pronounced cytotoxic activity against mammalian cells and microorganisms. Various aromatic selenocyanates have been synthesized and, similar to some of the most Reactive Sulfur Species (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/2/290 |
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| author | Muhammad Sarfraz Muhammad Jawad Nasim Martin C. H. Gruhlke Jadwiga Handzlik Claus Jacob |
| author_facet | Muhammad Sarfraz Muhammad Jawad Nasim Martin C. H. Gruhlke Jadwiga Handzlik Claus Jacob |
| author_sort | Muhammad Sarfraz |
| collection | DOAJ |
| description | Organic selenocyanates (RSeCN) are among the most reactive and biologically active Se species, often exhibiting a pronounced cytotoxic activity against mammalian cells and microorganisms. Various aromatic selenocyanates have been synthesized and, similar to some of the most Reactive Sulfur Species (RSS), such as allicin, found to be active against a range of bacteria, including <i>Escherichia coli</i>, <i>Pseudomonas syringae</i> and <i>Micrococcus luteus</i>, and fungi, including <i>Verticillium dahlia</i>, <i>Verticillium longisporum</i>, <i>Alternaria brassicicola</i>, and <i>Botrytis cinerea</i>, even via the gas phase. The highest antimicrobial activity has been observed for benzyl selenocyanate, which inhibited the growth of all bacteria considerably, even at the lowest tested concentration of 50 µM. Notably, neither the analogues thiocyanate (BTC) nor isothiocyanate (BITC) show any of these activities, rendering this selenium motif rather special in activity and mode of action. Eventually, these findings advocate a range of potential applications of organic selenocyanates in medicine and agriculture. |
| first_indexed | 2024-03-11T09:14:55Z |
| format | Article |
| id | doaj.art-4d3b3512aff14112b0c558f070f5588b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:14:55Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-4d3b3512aff14112b0c558f070f5588b2023-11-16T18:42:54ZengMDPI AGAntibiotics2079-63822023-02-0112229010.3390/antibiotics12020290To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas PhaseMuhammad Sarfraz0Muhammad Jawad Nasim1Martin C. H. Gruhlke2Jadwiga Handzlik3Claus Jacob4Department of Plant Physiology, RWTH Aachen University, Worringer Weg 1, 52056 Aachen, GermanyDivision of Bioorganic Chemistry, Saarland University, Campus B2 1, 66123 Saarbruecken, GermanyDepartment of Plant Physiology, RWTH Aachen University, Worringer Weg 1, 52056 Aachen, GermanyDepartment of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Cracow, PolandDivision of Bioorganic Chemistry, Saarland University, Campus B2 1, 66123 Saarbruecken, GermanyOrganic selenocyanates (RSeCN) are among the most reactive and biologically active Se species, often exhibiting a pronounced cytotoxic activity against mammalian cells and microorganisms. Various aromatic selenocyanates have been synthesized and, similar to some of the most Reactive Sulfur Species (RSS), such as allicin, found to be active against a range of bacteria, including <i>Escherichia coli</i>, <i>Pseudomonas syringae</i> and <i>Micrococcus luteus</i>, and fungi, including <i>Verticillium dahlia</i>, <i>Verticillium longisporum</i>, <i>Alternaria brassicicola</i>, and <i>Botrytis cinerea</i>, even via the gas phase. The highest antimicrobial activity has been observed for benzyl selenocyanate, which inhibited the growth of all bacteria considerably, even at the lowest tested concentration of 50 µM. Notably, neither the analogues thiocyanate (BTC) nor isothiocyanate (BITC) show any of these activities, rendering this selenium motif rather special in activity and mode of action. Eventually, these findings advocate a range of potential applications of organic selenocyanates in medicine and agriculture.https://www.mdpi.com/2079-6382/12/2/290gas phase activity(iso-)thiocyanatesmicrobiological assaysselenocyanates |
| spellingShingle | Muhammad Sarfraz Muhammad Jawad Nasim Martin C. H. Gruhlke Jadwiga Handzlik Claus Jacob To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase Antibiotics gas phase activity (iso-)thiocyanates microbiological assays selenocyanates |
| title | To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase |
| title_full | To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase |
| title_fullStr | To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase |
| title_full_unstemmed | To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase |
| title_short | To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase |
| title_sort | to cut the mustard antimicrobial activity of selenocyanates on the plate and in the gas phase |
| topic | gas phase activity (iso-)thiocyanates microbiological assays selenocyanates |
| url | https://www.mdpi.com/2079-6382/12/2/290 |
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