Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale?
Merkel cell carcinoma (MCC) is a rare, highly aggressive, neuroendocrine cutaneous tumor. The incidence of MCC is growing worldwide, and the disease-related mortality is about three-fold higher than melanoma. Since a few years ago, very little has been known about this disease, and chemotherapy has...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.739006/full |
| _version_ | 1819101022747885568 |
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| author | Enrica Teresa Tanda Enrica Teresa Tanda Agostina Lagodin d’Amato Agostina Lagodin d’Amato Giovanni Rossi Giovanni Rossi Elena Croce Elena Croce Andrea Boutros Andrea Boutros Federica Cecchi Francesco Spagnolo Paola Queirolo |
| author_facet | Enrica Teresa Tanda Enrica Teresa Tanda Agostina Lagodin d’Amato Agostina Lagodin d’Amato Giovanni Rossi Giovanni Rossi Elena Croce Elena Croce Andrea Boutros Andrea Boutros Federica Cecchi Francesco Spagnolo Paola Queirolo |
| author_sort | Enrica Teresa Tanda |
| collection | DOAJ |
| description | Merkel cell carcinoma (MCC) is a rare, highly aggressive, neuroendocrine cutaneous tumor. The incidence of MCC is growing worldwide, and the disease-related mortality is about three-fold higher than melanoma. Since a few years ago, very little has been known about this disease, and chemotherapy has been the standard of care. Nowadays, new discoveries about the pathophysiology of this neoplasm and the introduction of immunotherapy allowed to completely rewrite the history of these patients. In this review, we provide a summary of the most important changes in the management of Merkel cell carcinoma, with a focus on immunotherapy and a landscape of future treatment strategies. |
| first_indexed | 2024-12-22T01:12:04Z |
| format | Article |
| id | doaj.art-4d3b91d854e3417d88df24e41e4e5c45 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T01:12:04Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4d3b91d854e3417d88df24e41e4e5c452022-12-21T18:43:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.739006739006Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale?Enrica Teresa Tanda0Enrica Teresa Tanda1Agostina Lagodin d’Amato2Agostina Lagodin d’Amato3Giovanni Rossi4Giovanni Rossi5Elena Croce6Elena Croce7Andrea Boutros8Andrea Boutros9Federica Cecchi10Francesco Spagnolo11Paola Queirolo12Genetics of Rare Cancers, Department of Internal Medicine and Medical Specialties, University of Genoa, Genova, ItalyMedical Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genova, ItalyMedical Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genova, ItalyDepartment of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, ItalyMedical Oncology, Ospedale Padre Antero Micone, Genova, ItalyDepartment on Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, ItalyMedical Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genova, ItalyDepartment of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, ItalyMedical Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genova, ItalyDepartment of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, ItalyMedical Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genova, ItalyMedical Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genova, ItalyDivision of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, Istituto Europeo di Oncologia (IEO), European Institute of Oncology IRCCS, Milano, ItalyMerkel cell carcinoma (MCC) is a rare, highly aggressive, neuroendocrine cutaneous tumor. The incidence of MCC is growing worldwide, and the disease-related mortality is about three-fold higher than melanoma. Since a few years ago, very little has been known about this disease, and chemotherapy has been the standard of care. Nowadays, new discoveries about the pathophysiology of this neoplasm and the introduction of immunotherapy allowed to completely rewrite the history of these patients. In this review, we provide a summary of the most important changes in the management of Merkel cell carcinoma, with a focus on immunotherapy and a landscape of future treatment strategies.https://www.frontiersin.org/articles/10.3389/fonc.2021.739006/fullmerkel cell carcinomaimmunotherapymerkel cell polyomavirusadvanced diseaseanti-PD-1neoadjuvant |
| spellingShingle | Enrica Teresa Tanda Enrica Teresa Tanda Agostina Lagodin d’Amato Agostina Lagodin d’Amato Giovanni Rossi Giovanni Rossi Elena Croce Elena Croce Andrea Boutros Andrea Boutros Federica Cecchi Francesco Spagnolo Paola Queirolo Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale? Frontiers in Oncology merkel cell carcinoma immunotherapy merkel cell polyomavirus advanced disease anti-PD-1 neoadjuvant |
| title | Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale? |
| title_full | Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale? |
| title_fullStr | Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale? |
| title_full_unstemmed | Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale? |
| title_short | Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale? |
| title_sort | merkel cell carcinoma an immunotherapy fairy tale |
| topic | merkel cell carcinoma immunotherapy merkel cell polyomavirus advanced disease anti-PD-1 neoadjuvant |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.739006/full |
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