KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance

KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance

KDM5A and KDM5B histone-demethylases are overexpressed in many cancers and have been involved in drug tolerance. Here, we describe that KDM5A, together with KDM5B, contribute to replication stress (RS) response and tolerance. First, they positively regulate RRM2, the regulatory subunit of ribonucleo...

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Bibliographic Details
Main Authors: Solenne Gaillard, Virginie Charasson, Cyril Ribeyre, Kader Salifou, Marie-Jeanne Pillaire, Jean-Sebastien Hoffmann, Angelos Constantinou, Didier Trouche, Marie Vandromme
Format: Article
Language:English
Published: The Company of Biologists 2021-05-01
Series:Biology Open
Subjects:
chromatin
drug tolerance
replication stress
Online Access:http://bio.biologists.org/content/10/5/bio057729

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