The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer
Cancer remains one of the most common causes of death and disability and represents a major economic burden in industrialized nations. The renin-angiotensin system (RAS) has been well-recognized as one of the most important regulators of both normal and pathological physiological processes in the br...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00276/full |
| _version_ | 1819206942306861056 |
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| author | Juanjuan Xu Jinshuo Fan Feng Wu Qi Huang Mengfei Guo Zhilei Lv Jieli Han Limin Duan Guorong Hu Lian Chen Tingting Liao Wanli Ma Xiaonan Tao Yang Jin |
| author_facet | Juanjuan Xu Jinshuo Fan Feng Wu Qi Huang Mengfei Guo Zhilei Lv Jieli Han Limin Duan Guorong Hu Lian Chen Tingting Liao Wanli Ma Xiaonan Tao Yang Jin |
| author_sort | Juanjuan Xu |
| collection | DOAJ |
| description | Cancer remains one of the most common causes of death and disability and represents a major economic burden in industrialized nations. The renin-angiotensin system (RAS) has been well-recognized as one of the most important regulators of both normal and pathological physiological processes in the brain, kidney, heart, and blood vessels. The activation of the angiotensin-converting enzyme 2/angiotensin-(1–7)/mitochondrial assembly receptor [ACE2/Ang-(1–7)/MasR] axis, which is one component of the RAS, has recently been identified as a critical component of pulmonary systems, gastric mucosa, and cancer. However, the ability of the ACE2/Ang-(1–7)/MasR axis to suppress or promote cancer has not been fully elucidated. In this review, we focus on recent experimental and clinical studies investigating the basic properties, roles, and mechanisms of ACE2, Ang-(1–7), and the MasR, as well as the axis pathway, to provide insights into possible therapeutic strategies for treating cancer that target the ACE2/Ang-(1–7)/MasR axis. |
| first_indexed | 2024-12-23T05:15:37Z |
| format | Article |
| id | doaj.art-4d3ede9578af4994bc3c47dfe07af6c6 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-23T05:15:37Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-4d3ede9578af4994bc3c47dfe07af6c62022-12-21T17:58:50ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-05-01810.3389/fphys.2017.00276258794The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in CancerJuanjuan XuJinshuo FanFeng WuQi HuangMengfei GuoZhilei LvJieli HanLimin DuanGuorong HuLian ChenTingting LiaoWanli MaXiaonan TaoYang JinCancer remains one of the most common causes of death and disability and represents a major economic burden in industrialized nations. The renin-angiotensin system (RAS) has been well-recognized as one of the most important regulators of both normal and pathological physiological processes in the brain, kidney, heart, and blood vessels. The activation of the angiotensin-converting enzyme 2/angiotensin-(1–7)/mitochondrial assembly receptor [ACE2/Ang-(1–7)/MasR] axis, which is one component of the RAS, has recently been identified as a critical component of pulmonary systems, gastric mucosa, and cancer. However, the ability of the ACE2/Ang-(1–7)/MasR axis to suppress or promote cancer has not been fully elucidated. In this review, we focus on recent experimental and clinical studies investigating the basic properties, roles, and mechanisms of ACE2, Ang-(1–7), and the MasR, as well as the axis pathway, to provide insights into possible therapeutic strategies for treating cancer that target the ACE2/Ang-(1–7)/MasR axis.http://journal.frontiersin.org/article/10.3389/fphys.2017.00276/fullrenin-angiotensin system (RAS)angiotensin-converting enzyme 2 (ACE2)angiotensin-(1–7)Mas receptorcancerdrug resistance |
| spellingShingle | Juanjuan Xu Jinshuo Fan Feng Wu Qi Huang Mengfei Guo Zhilei Lv Jieli Han Limin Duan Guorong Hu Lian Chen Tingting Liao Wanli Ma Xiaonan Tao Yang Jin The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer Frontiers in Physiology renin-angiotensin system (RAS) angiotensin-converting enzyme 2 (ACE2) angiotensin-(1–7) Mas receptor cancer drug resistance |
| title | The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer |
| title_full | The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer |
| title_fullStr | The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer |
| title_full_unstemmed | The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer |
| title_short | The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer |
| title_sort | ace2 angiotensin 1 7 mas receptor axis pleiotropic roles in cancer |
| topic | renin-angiotensin system (RAS) angiotensin-converting enzyme 2 (ACE2) angiotensin-(1–7) Mas receptor cancer drug resistance |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00276/full |
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