Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients
Abstract Objectives In this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated radiotherapy in individuals who had undergone surgery for breast cancer. Methods This study involved a systematic and independent review of rele...
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| Format: | Article |
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BMC
2024-02-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-11918-2 |
| _version_ | 1797274294680551424 |
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| author | Yongkai Lu Beina Hui Di Yang Yi Li Binglin Li Luping Zhou Lei Xu Fengwen Tang Wei Wang Ruijuan Chen Dongli Zhao |
| author_facet | Yongkai Lu Beina Hui Di Yang Yi Li Binglin Li Luping Zhou Lei Xu Fengwen Tang Wei Wang Ruijuan Chen Dongli Zhao |
| author_sort | Yongkai Lu |
| collection | DOAJ |
| description | Abstract Objectives In this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated radiotherapy in individuals who had undergone surgery for breast cancer. Methods This study involved a systematic and independent review of relevant research articles published in reputable databases such as PubMed, Embase, Cochrane Library, and Web of Science. Two investigators conducted the review, which included studies published up to January 3, 2023. The quality of the eligible studies was evaluated and data were extracted using Review Manager software 5.4 (RevMan 5.4) to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results The analysis comprised 35 studies and encompassed a collective sample of 18,246 individuals diagnosed with breast cancer. We did not find a statistically significant disparity in efficacy between conventional fractionated (CF) radiotherapy and hypofractionated (HF) radiotherapy regarding local recurrence (LR; OR = 0.91, 95% CI: 0.76–1.09, P = 0.30), disease-free survival (DFS; OR = 1.20, 95% CI: 1.01–1.42, P = 0.03), and overall survival (OS; OR = 1.08, 95% CI: 0.93–1.26, P = 0.28). Concerning safety, there was no significant difference between the HF and CF regimens in terms of breast pain, breast atrophy, lymphedema, pneumonia, pulmonary fibrosis, telangiectasia, and cardiotoxicity. However, the HF regimen resulted in lower skin toxicity (OR = 0.43, 95% CI: 0.33—0.55, P < 0.01) and improved patient fatigue outcomes (OR = 0.73, 95% CI: 0.60 – 0.88, P < 0.01). Conclusions Although there is no substantial difference in LR, DFS, OS, or many other side effects between the HF and CF regimens, the HF regimen reduces skin toxicity and relieves patient fatigue. If these two issues need to be addressed in clinical situations, the HF regimen may be a superior alternative to conventional radiotherapy in postoperative breast cancer patients. |
| first_indexed | 2024-03-07T14:56:20Z |
| format | Article |
| id | doaj.art-4d412bce6bbf48bfb013afad18960a79 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-07T14:56:20Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-4d412bce6bbf48bfb013afad18960a792024-03-05T19:24:07ZengBMCBMC Cancer1471-24072024-02-0124111810.1186/s12885-024-11918-2Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patientsYongkai Lu0Beina Hui1Di Yang2Yi Li3Binglin Li4Luping Zhou5Lei Xu6Fengwen Tang7Wei Wang8Ruijuan Chen9Dongli Zhao10Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, Shaanxi Provincial Tumor Hospital, Affiliated Hospital of Xi’an Jiaotong University Health Science CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Obstetrics and Gynecology, Xi’an Central Hospital, the Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, Xijing Hospital, Air Force Medical UniversityDepartment of Obstetrics and Gynecology, Xi’an Central Hospital, the Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Objectives In this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated radiotherapy in individuals who had undergone surgery for breast cancer. Methods This study involved a systematic and independent review of relevant research articles published in reputable databases such as PubMed, Embase, Cochrane Library, and Web of Science. Two investigators conducted the review, which included studies published up to January 3, 2023. The quality of the eligible studies was evaluated and data were extracted using Review Manager software 5.4 (RevMan 5.4) to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results The analysis comprised 35 studies and encompassed a collective sample of 18,246 individuals diagnosed with breast cancer. We did not find a statistically significant disparity in efficacy between conventional fractionated (CF) radiotherapy and hypofractionated (HF) radiotherapy regarding local recurrence (LR; OR = 0.91, 95% CI: 0.76–1.09, P = 0.30), disease-free survival (DFS; OR = 1.20, 95% CI: 1.01–1.42, P = 0.03), and overall survival (OS; OR = 1.08, 95% CI: 0.93–1.26, P = 0.28). Concerning safety, there was no significant difference between the HF and CF regimens in terms of breast pain, breast atrophy, lymphedema, pneumonia, pulmonary fibrosis, telangiectasia, and cardiotoxicity. However, the HF regimen resulted in lower skin toxicity (OR = 0.43, 95% CI: 0.33—0.55, P < 0.01) and improved patient fatigue outcomes (OR = 0.73, 95% CI: 0.60 – 0.88, P < 0.01). Conclusions Although there is no substantial difference in LR, DFS, OS, or many other side effects between the HF and CF regimens, the HF regimen reduces skin toxicity and relieves patient fatigue. If these two issues need to be addressed in clinical situations, the HF regimen may be a superior alternative to conventional radiotherapy in postoperative breast cancer patients.https://doi.org/10.1186/s12885-024-11918-2Breast cancerHypofractionated radiotherapyConventional fractionated radiotherapyMeta-analysis |
| spellingShingle | Yongkai Lu Beina Hui Di Yang Yi Li Binglin Li Luping Zhou Lei Xu Fengwen Tang Wei Wang Ruijuan Chen Dongli Zhao Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients BMC Cancer Breast cancer Hypofractionated radiotherapy Conventional fractionated radiotherapy Meta-analysis |
| title | Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients |
| title_full | Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients |
| title_fullStr | Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients |
| title_full_unstemmed | Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients |
| title_short | Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients |
| title_sort | efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients |
| topic | Breast cancer Hypofractionated radiotherapy Conventional fractionated radiotherapy Meta-analysis |
| url | https://doi.org/10.1186/s12885-024-11918-2 |
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