Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease
Parkinson's disease can affect not only motor functions but also cognitive abilities, leading to cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction is the difficulty in executive functioning. Executive functions help us plan, organize, and control our...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1759;epage=1767;aulast=Zhou |
| _version_ | 1827300194801156096 |
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| author | Zihang Zhou Yalong Yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang |
| author_facet | Zihang Zhou Yalong Yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang |
| author_sort | Zihang Zhou |
| collection | DOAJ |
| description | Parkinson's disease can affect not only motor functions but also cognitive abilities, leading to cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction is the difficulty in executive functioning. Executive functions help us plan, organize, and control our actions based on our goals. The brain area responsible for executive functions is called the prefrontal cortex. It acts as the command center for the brain, especially when it comes to regulating executive functions. The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine. However, little is known about how dopamine affects the cognitive functions of patients with Parkinson's disease. In this article, the authors review the latest research on this topic. They start by looking at how the dopaminergic system, is altered in Parkinson's disease with executive dysfunction. Then, they explore how these changes in dopamine impact the synaptic structure, electrical activity, and connection components of the prefrontal cortex. The authors also summarize the relationship between Parkinson's disease and dopamine-related cognitive issues. This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson's disease. |
| first_indexed | 2024-04-24T15:48:00Z |
| format | Article |
| id | doaj.art-4d43f9569578452680bda09ef6878454 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-24T15:48:00Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-4d43f9569578452680bda09ef68784542024-04-01T13:06:21ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-011981759176710.4103/1673-5374.389631Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's diseaseZihang ZhouYalong YanHeng GuRuiao SunZihan LiaoKe XueChuanxi TangParkinson's disease can affect not only motor functions but also cognitive abilities, leading to cognitive impairment. One common issue in Parkinson's disease with cognitive dysfunction is the difficulty in executive functioning. Executive functions help us plan, organize, and control our actions based on our goals. The brain area responsible for executive functions is called the prefrontal cortex. It acts as the command center for the brain, especially when it comes to regulating executive functions. The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine. However, little is known about how dopamine affects the cognitive functions of patients with Parkinson's disease. In this article, the authors review the latest research on this topic. They start by looking at how the dopaminergic system, is altered in Parkinson's disease with executive dysfunction. Then, they explore how these changes in dopamine impact the synaptic structure, electrical activity, and connection components of the prefrontal cortex. The authors also summarize the relationship between Parkinson's disease and dopamine-related cognitive issues. This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson's disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1759;epage=1767;aulast=Zhoudopamine; dopamine receptor; dopamine transporter; executive dysfunction; neural network; neural oscillation; prefrontal cortex; synaptic plasticity |
| spellingShingle | Zihang Zhou Yalong Yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease Neural Regeneration Research dopamine; dopamine receptor; dopamine transporter; executive dysfunction; neural network; neural oscillation; prefrontal cortex; synaptic plasticity |
| title | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease |
| title_full | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease |
| title_fullStr | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease |
| title_full_unstemmed | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease |
| title_short | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease |
| title_sort | dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with parkinson s disease |
| topic | dopamine; dopamine receptor; dopamine transporter; executive dysfunction; neural network; neural oscillation; prefrontal cortex; synaptic plasticity |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1759;epage=1767;aulast=Zhou |
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