Enhanced Cytotoxic Effects of Arenite in Combination with Active Bufadienolide Compounds against Human Glioblastoma Cell Line U-87

Enhanced Cytotoxic Effects of Arenite in Combination with Active Bufadienolide Compounds against Human Glioblastoma Cell Line U-87

The cytotoxicity of a trivalent arsenic derivative (arsenite, As<sup>III</sup>) combined with arenobufagin or gamabufotalin was evaluated in human U-87 glioblastoma cells. Synergistic cytotoxicity with upregulated intracellular arsenic levels was observed, when treated with As<sup>...

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Bibliographic Details
Main Authors: Bo Yuan, Jingmei Li, Shin-Ich Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Takeshi Sakamoto, Yasuhide Hibino, Mari Okazaki
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
arsenite
arenobufagin
gamabufotalin
glioblastoma
DNA damage
cell death
Online Access:https://www.mdpi.com/1420-3049/27/19/6577

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