The role of hormones in renal disease and ischemia-reperfusion injury
The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflamma...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-05-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_12448_aa0d7fad5b22dc3f4b91e296f23bc42e.pdf |
| _version_ | 1818068522372169728 |
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| author | Shokofeh Banaei Lotfollah Rezagholizadeh |
| author_facet | Shokofeh Banaei Lotfollah Rezagholizadeh |
| author_sort | Shokofeh Banaei |
| collection | DOAJ |
| description | The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation is considered the choice treatment for patients with ESRD. Ischemia-reperfusion (IR), which occurs during renal transplantation is one of the factors that affect the outcome of renal transplantation. Renal graft rejection is the result of IR injury and there is no effective treatment to prevent IR injury. Reperfusion after ischemia may cause injury through generation of reactive oxygen and nitrogen species, inflammatory responses by increased levels of tumor necrosis factor-α (TNF-α) and interleukins (IL), and apoptotic processes, and leads to acute kidney injury (AKI). Thus, antioxidant, anti-apoptotic and anti-inflammatory hormones, which inhibit these pathways, can protect against IR injury and improve transplanted renal function in patients with ESRD. |
| first_indexed | 2024-12-10T15:40:55Z |
| format | Article |
| id | doaj.art-4d45ee75111c4889815516d4c6f474e7 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-10T15:40:55Z |
| publishDate | 2019-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-4d45ee75111c4889815516d4c6f474e72022-12-22T01:43:06ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742019-05-0122546947610.22038/ijbms.2019.34037.809512448The role of hormones in renal disease and ischemia-reperfusion injuryShokofeh Banaei0Lotfollah Rezagholizadeh1Social Determinants of Health (SDH) Research Center, Ardabil University of Medical Sciences, Ardabil, Iran|Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranDepartment of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, IranThe patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation is considered the choice treatment for patients with ESRD. Ischemia-reperfusion (IR), which occurs during renal transplantation is one of the factors that affect the outcome of renal transplantation. Renal graft rejection is the result of IR injury and there is no effective treatment to prevent IR injury. Reperfusion after ischemia may cause injury through generation of reactive oxygen and nitrogen species, inflammatory responses by increased levels of tumor necrosis factor-α (TNF-α) and interleukins (IL), and apoptotic processes, and leads to acute kidney injury (AKI). Thus, antioxidant, anti-apoptotic and anti-inflammatory hormones, which inhibit these pathways, can protect against IR injury and improve transplanted renal function in patients with ESRD.http://ijbms.mums.ac.ir/article_12448_aa0d7fad5b22dc3f4b91e296f23bc42e.pdfAcute kidney injury AntioxidantHormonesIschemia-reperfusion injuryRenal disease |
| spellingShingle | Shokofeh Banaei Lotfollah Rezagholizadeh The role of hormones in renal disease and ischemia-reperfusion injury Iranian Journal of Basic Medical Sciences Acute kidney injury Antioxidant Hormones Ischemia-reperfusion injury Renal disease |
| title | The role of hormones in renal disease and ischemia-reperfusion injury |
| title_full | The role of hormones in renal disease and ischemia-reperfusion injury |
| title_fullStr | The role of hormones in renal disease and ischemia-reperfusion injury |
| title_full_unstemmed | The role of hormones in renal disease and ischemia-reperfusion injury |
| title_short | The role of hormones in renal disease and ischemia-reperfusion injury |
| title_sort | role of hormones in renal disease and ischemia reperfusion injury |
| topic | Acute kidney injury Antioxidant Hormones Ischemia-reperfusion injury Renal disease |
| url | http://ijbms.mums.ac.ir/article_12448_aa0d7fad5b22dc3f4b91e296f23bc42e.pdf |
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