Ferroptosis in osteosarcoma: A promising future
The incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-depend...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031779/full |
| _version_ | 1811180021869445120 |
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| author | Xiang Liu Xiang Liu Shaowen Du Shaowen Du Shengdong Wang Shengdong Wang Kaishan Ye |
| author_facet | Xiang Liu Xiang Liu Shaowen Du Shaowen Du Shengdong Wang Shengdong Wang Kaishan Ye |
| author_sort | Xiang Liu |
| collection | DOAJ |
| description | The incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-dependent lipid peroxidation. Current studies have shown that ferroptosis is closely related to OS and could reduce chemotherapy resistance to a certain extent, which has great therapeutic potential. In this paper, we review the regulatory mechanism of ferroptosis and its research progress in OS, hoping to provide new help for the clinical treatment of OS. |
| first_indexed | 2024-04-11T06:44:32Z |
| format | Article |
| id | doaj.art-4d484423fefd44e588a86bd67a7df65f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T06:44:32Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4d484423fefd44e588a86bd67a7df65f2022-12-22T04:39:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10317791031779Ferroptosis in osteosarcoma: A promising futureXiang Liu0Xiang Liu1Shaowen Du2Shaowen Du3Shengdong Wang4Shengdong Wang5Kaishan Ye6Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of Bone and Joint Diseases of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of Bone and Joint Diseases of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, ChinaKey Laboratory of Bone and Joint Diseases of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, ChinaThe incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-dependent lipid peroxidation. Current studies have shown that ferroptosis is closely related to OS and could reduce chemotherapy resistance to a certain extent, which has great therapeutic potential. In this paper, we review the regulatory mechanism of ferroptosis and its research progress in OS, hoping to provide new help for the clinical treatment of OS.https://www.frontiersin.org/articles/10.3389/fonc.2022.1031779/fullferroptosisosteosarcomamolecular mechanismstumor treatmentchemotherapy resistance |
| spellingShingle | Xiang Liu Xiang Liu Shaowen Du Shaowen Du Shengdong Wang Shengdong Wang Kaishan Ye Ferroptosis in osteosarcoma: A promising future Frontiers in Oncology ferroptosis osteosarcoma molecular mechanisms tumor treatment chemotherapy resistance |
| title | Ferroptosis in osteosarcoma: A promising future |
| title_full | Ferroptosis in osteosarcoma: A promising future |
| title_fullStr | Ferroptosis in osteosarcoma: A promising future |
| title_full_unstemmed | Ferroptosis in osteosarcoma: A promising future |
| title_short | Ferroptosis in osteosarcoma: A promising future |
| title_sort | ferroptosis in osteosarcoma a promising future |
| topic | ferroptosis osteosarcoma molecular mechanisms tumor treatment chemotherapy resistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031779/full |
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