Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders
Increasing rates of overdose and overdose deaths are a significant public health problem. Research has examined co-occurring mental health conditions, including suicidality, as a risk factor for intentional and unintentional overdose among individuals with substance use disorder (SUD). However, this...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6400 |
| _version_ | 1797467776996081664 |
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| author | Viviana E. Horigian Renae D. Schmidt Dikla Shmueli-Blumberg Kathryn Hefner Judith Feinberg Radhika Kondapaka Daniel J. Feaster Rui Duan Sophia Gonzalez Carly Davis Rodrigo Marín-Navarrete Susan Tross |
| author_facet | Viviana E. Horigian Renae D. Schmidt Dikla Shmueli-Blumberg Kathryn Hefner Judith Feinberg Radhika Kondapaka Daniel J. Feaster Rui Duan Sophia Gonzalez Carly Davis Rodrigo Marín-Navarrete Susan Tross |
| author_sort | Viviana E. Horigian |
| collection | DOAJ |
| description | Increasing rates of overdose and overdose deaths are a significant public health problem. Research has examined co-occurring mental health conditions, including suicidality, as a risk factor for intentional and unintentional overdose among individuals with substance use disorder (SUD). However, this research has been limited to single site studies of self-reported outcomes. The current research evaluated suicidality as a predictor of overdose events in 2541 participants who use substances enrolled across eight multi-site clinical trials completed within the National Drug Abuse Treatment Clinical Trials Network between 2012 to 2021. The trials assessed baseline suicidality with the Concise Health Risk Tracking Self-Report (CHRT-SR). Overdose events were determined by reports of adverse events, cause of death, or hospitalization due to substance overdose, and verified through a rigorous adjudication process. Multivariate logistic regression was performed to assess continuous CHRT-SR score as a predictor of overdose, controlling for covariates. CHRT-SR score was associated with overdose events (<i>p</i> = 0.03) during the trial; the likelihood of overdose increased as continuous CHRT score increased (OR 1.02). Participants with lifetime heroin use were more likely to overdose (OR 3.08). Response to the marked rise in overdose deaths should integrate suicide risk reduction as part of prevention strategies. |
| first_indexed | 2024-03-09T18:57:34Z |
| format | Article |
| id | doaj.art-4d4bffd715b2471091c947f4b1ef3d07 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:57:34Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4d4bffd715b2471091c947f4b1ef3d072023-11-24T05:17:04ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121640010.3390/jcm11216400Suicidality as a Predictor of Overdose among Patients with Substance Use DisordersViviana E. Horigian0Renae D. Schmidt1Dikla Shmueli-Blumberg2Kathryn Hefner3Judith Feinberg4Radhika Kondapaka5Daniel J. Feaster6Rui Duan7Sophia Gonzalez8Carly Davis9Rodrigo Marín-Navarrete10Susan Tross11Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Miami, FL 33136, USADepartment of Public Health Sciences, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Miami, FL 33136, USAThe Emmes Company, LLC, 401 N. Washington St., Suite 700, Rockville, MD 20850, USAThe Emmes Company, LLC, 401 N. Washington St., Suite 700, Rockville, MD 20850, USADepartments of Behavioral Medicine and Psychiatry & Medicine/Infectious Diseases, West Virginia University School of Medicine, 930 Chestnut Ridge Road, Morgantown, WV 26505, USAThe Emmes Company, LLC, 401 N. Washington St., Suite 700, Rockville, MD 20850, USADepartment of Public Health Sciences, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Miami, FL 33136, USADepartment of Public Health Sciences, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Miami, FL 33136, USADepartment of Public Health Sciences, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Miami, FL 33136, USADepartment of Public Health Sciences, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Miami, FL 33136, USADivision of Research and Translational Education, Centros de Integración Juvenil A.C., San Jerónimo Avenue 372, Jardines del Pedregal, Mexico City 01900, MexicoDepartment of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USAIncreasing rates of overdose and overdose deaths are a significant public health problem. Research has examined co-occurring mental health conditions, including suicidality, as a risk factor for intentional and unintentional overdose among individuals with substance use disorder (SUD). However, this research has been limited to single site studies of self-reported outcomes. The current research evaluated suicidality as a predictor of overdose events in 2541 participants who use substances enrolled across eight multi-site clinical trials completed within the National Drug Abuse Treatment Clinical Trials Network between 2012 to 2021. The trials assessed baseline suicidality with the Concise Health Risk Tracking Self-Report (CHRT-SR). Overdose events were determined by reports of adverse events, cause of death, or hospitalization due to substance overdose, and verified through a rigorous adjudication process. Multivariate logistic regression was performed to assess continuous CHRT-SR score as a predictor of overdose, controlling for covariates. CHRT-SR score was associated with overdose events (<i>p</i> = 0.03) during the trial; the likelihood of overdose increased as continuous CHRT score increased (OR 1.02). Participants with lifetime heroin use were more likely to overdose (OR 3.08). Response to the marked rise in overdose deaths should integrate suicide risk reduction as part of prevention strategies.https://www.mdpi.com/2077-0383/11/21/6400substance use disordersdual disordersco-occurring disorderssuicidalityoverdose |
| spellingShingle | Viviana E. Horigian Renae D. Schmidt Dikla Shmueli-Blumberg Kathryn Hefner Judith Feinberg Radhika Kondapaka Daniel J. Feaster Rui Duan Sophia Gonzalez Carly Davis Rodrigo Marín-Navarrete Susan Tross Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders Journal of Clinical Medicine substance use disorders dual disorders co-occurring disorders suicidality overdose |
| title | Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders |
| title_full | Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders |
| title_fullStr | Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders |
| title_full_unstemmed | Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders |
| title_short | Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders |
| title_sort | suicidality as a predictor of overdose among patients with substance use disorders |
| topic | substance use disorders dual disorders co-occurring disorders suicidality overdose |
| url | https://www.mdpi.com/2077-0383/11/21/6400 |
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