Unconjugated Hyperbilirubinemia after Open Heart Surgery
The occurrence of hyperbilirubinaemia after heart surgery using cardiopulmonary bypass or post-operative heart failure is fairly common. Mechanism of hyperbilirubinemiais still not completely clarified, and there are so few specific therapies available for acute hepatobiliary injury. Post-operative...
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| Format: | Article |
| Language: | English |
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Albanian Society for Trauma and Emergency Surgery
2020-01-01
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| Series: | Albanian Journal of Trauma and Emergency Surgery |
| Subjects: | |
| Online Access: | http://journal.astes.org.al/index.php/AJTES/article/view/84 |
| _version_ | 1828971248013541376 |
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| author | Alfred Ibrahimi Saimir Kuci Ervin Bejko Stavri Llazo Jehona Neziraj Jacob Zeitani Edvin Prifti |
| author_facet | Alfred Ibrahimi Saimir Kuci Ervin Bejko Stavri Llazo Jehona Neziraj Jacob Zeitani Edvin Prifti |
| author_sort | Alfred Ibrahimi |
| collection | DOAJ |
| description | The occurrence of hyperbilirubinaemia after heart surgery using cardiopulmonary bypass or post-operative heart failure is fairly common. Mechanism of hyperbilirubinemiais still not completely clarified, and there are so few specific therapies available for acute hepatobiliary injury. Post-operative mortality well correlates with increasing total bilirubin values, particularly for bilirubin-associate acute kidney tubular necrosis. The difficulty to reduce mortality is partially a consequence of not completely understood physiopathology. It is obvious that long-lasting CPB plays an important role, in association with hemodilution, hypotension, ischemia-reperfusion, and increasing hematic level of endogenous catecholamine with reduction of hepatic blood flow. Case report. A 68 years old man with severe mitral valve regurgitation and pulmonary hypertension and low EF 30%. Mitral valve replacement and tricuspid anuloplastic was performed. Due to low cardiac output syndrome severe hyperbilirubiemeia was seen (24 mg/dl. and unconjugated fraction 16mg/dl) days after. Phenobarbital (luminal) was started 15 mg/kg daily. Two days later the level decreased until 8 mg/dl with normalization of conjugation/unconjugation ratio.Postoperative hyperbilirubinemia is a multifactorial process caused by both impaired liver function of bilirubin transport. In case of elevated level of unconjugated fraction we suggest to use Luminal as alternative for decreasing unconjugated fraction. |
| first_indexed | 2024-12-14T13:06:42Z |
| format | Article |
| id | doaj.art-4d4ea8392e1443f0a26ab47ef1f5cf79 |
| institution | Directory Open Access Journal |
| issn | 2521-8778 2616-4922 |
| language | English |
| last_indexed | 2024-12-14T13:06:42Z |
| publishDate | 2020-01-01 |
| publisher | Albanian Society for Trauma and Emergency Surgery |
| record_format | Article |
| series | Albanian Journal of Trauma and Emergency Surgery |
| spelling | doaj.art-4d4ea8392e1443f0a26ab47ef1f5cf792022-12-21T23:00:18ZengAlbanian Society for Trauma and Emergency SurgeryAlbanian Journal of Trauma and Emergency Surgery2521-87782616-49222020-01-014110.32391/ajtes.v4i1.84Unconjugated Hyperbilirubinemia after Open Heart SurgeryAlfred Ibrahimi0Saimir Kuci1Ervin Bejko2Stavri Llazo3Jehona Neziraj4Jacob Zeitani5Edvin Prifti6Service of Anesthesia, University Hospital Center, "Mother Teresa", Tirana, AlbaniaService of Anesthesia, University Hospital Center, "Mother Teresa", Tirana, AlbaniaService of Anesthesia, University Hospital Center, "Mother Teresa", Tirana, AlbaniaService of Anesthesia, University Hospital Center, "Mother Teresa", Tirana, AlbaniaCardiac surgery -service “German International Hospital” , Tirana, AlbaniaCardiac surgery -service “German International Hospital”, Tirana, AlbaniaCardiac surgery service, University Hospital Center, "Mother Teresa", Tirana, AlbaniaThe occurrence of hyperbilirubinaemia after heart surgery using cardiopulmonary bypass or post-operative heart failure is fairly common. Mechanism of hyperbilirubinemiais still not completely clarified, and there are so few specific therapies available for acute hepatobiliary injury. Post-operative mortality well correlates with increasing total bilirubin values, particularly for bilirubin-associate acute kidney tubular necrosis. The difficulty to reduce mortality is partially a consequence of not completely understood physiopathology. It is obvious that long-lasting CPB plays an important role, in association with hemodilution, hypotension, ischemia-reperfusion, and increasing hematic level of endogenous catecholamine with reduction of hepatic blood flow. Case report. A 68 years old man with severe mitral valve regurgitation and pulmonary hypertension and low EF 30%. Mitral valve replacement and tricuspid anuloplastic was performed. Due to low cardiac output syndrome severe hyperbilirubiemeia was seen (24 mg/dl. and unconjugated fraction 16mg/dl) days after. Phenobarbital (luminal) was started 15 mg/kg daily. Two days later the level decreased until 8 mg/dl with normalization of conjugation/unconjugation ratio.Postoperative hyperbilirubinemia is a multifactorial process caused by both impaired liver function of bilirubin transport. In case of elevated level of unconjugated fraction we suggest to use Luminal as alternative for decreasing unconjugated fraction.http://journal.astes.org.al/index.php/AJTES/article/view/84Unconjugated HyperbilirubinaemiaCardiopulmonary bypassLuminal |
| spellingShingle | Alfred Ibrahimi Saimir Kuci Ervin Bejko Stavri Llazo Jehona Neziraj Jacob Zeitani Edvin Prifti Unconjugated Hyperbilirubinemia after Open Heart Surgery Albanian Journal of Trauma and Emergency Surgery Unconjugated Hyperbilirubinaemia Cardiopulmonary bypass Luminal |
| title | Unconjugated Hyperbilirubinemia after Open Heart Surgery |
| title_full | Unconjugated Hyperbilirubinemia after Open Heart Surgery |
| title_fullStr | Unconjugated Hyperbilirubinemia after Open Heart Surgery |
| title_full_unstemmed | Unconjugated Hyperbilirubinemia after Open Heart Surgery |
| title_short | Unconjugated Hyperbilirubinemia after Open Heart Surgery |
| title_sort | unconjugated hyperbilirubinemia after open heart surgery |
| topic | Unconjugated Hyperbilirubinaemia Cardiopulmonary bypass Luminal |
| url | http://journal.astes.org.al/index.php/AJTES/article/view/84 |
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