Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD)

Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD)

9′-<i>cis</i>-norbixin (norbixin/BIO201) protects RPE cells against phototoxicity induced by blue light and <i>N</i>-retinylidene-<i>N</i>-retinylethanolamine (A2E) in vitro and preserves visual functions in animal models of age-related macular degeneration (AMD)...

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Bibliographic Details
Main Authors: Valérie Fontaine, Christine Balducci, Laurence Dinan, Elodie Monteiro, Thinhinane Boumedine, Mylène Fournié, Vincent Nguyen, Louis Guibout, Justine Clatot, Mathilde Latil, Stanislas Veillet, José-Alain Sahel, René Lafont, Pierre J. Dilda, Serge Camelo
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
A2E
AMD
eye
norbixin-conjugate
pharmacokinetics
PPARs
Online Access:https://www.mdpi.com/1422-0067/24/6/5296

Internet

https://www.mdpi.com/1422-0067/24/6/5296

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