High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species
Hybridization is increasingly being recognized as a common process in both animal and plant species. Negative epistatic interactions between genes from different parental genomes decrease the fitness of hybrids and can limit gene flow between species. However, little is known about the number and ge...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/02535 |
| _version_ | 1828167516236546048 |
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| author | Molly Schumer Rongfeng Cui Daniel L Powell Rebecca Dresner Gil G Rosenthal Peter Andolfatto |
| author_facet | Molly Schumer Rongfeng Cui Daniel L Powell Rebecca Dresner Gil G Rosenthal Peter Andolfatto |
| author_sort | Molly Schumer |
| collection | DOAJ |
| description | Hybridization is increasingly being recognized as a common process in both animal and plant species. Negative epistatic interactions between genes from different parental genomes decrease the fitness of hybrids and can limit gene flow between species. However, little is known about the number and genome-wide distribution of genetic incompatibilities separating species. To detect interacting genes, we perform a high-resolution genome scan for linkage disequilibrium between unlinked genomic regions in naturally occurring hybrid populations of swordtail fish. We estimate that hundreds of pairs of genomic regions contribute to reproductive isolation between these species, despite them being recently diverged. Many of these incompatibilities are likely the result of natural or sexual selection on hybrids, since intrinsic isolation is known to be weak. Patterns of genomic divergence at these regions imply that genetic incompatibilities play a significant role in limiting gene flow even in young species. |
| first_indexed | 2024-04-12T02:17:50Z |
| format | Article |
| id | doaj.art-4d50244846f645318675335e7de0b666 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:17:50Z |
| publishDate | 2014-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4d50244846f645318675335e7de0b6662022-12-22T03:52:12ZengeLife Sciences Publications LtdeLife2050-084X2014-06-01310.7554/eLife.02535High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish speciesMolly Schumer0Rongfeng Cui1Daniel L Powell2Rebecca Dresner3Gil G Rosenthal4Peter Andolfatto5Department of Ecology and Evolutionary Biology, Princeton University, Princeton, United StatesDepartment of Biology, Texas A&M University, College Station, United States; Centro de Investigaciones Científicas de las Huastecas 'Aguazarca', Calnali, MexicoDepartment of Biology, Texas A&M University, College Station, United States; Centro de Investigaciones Científicas de las Huastecas 'Aguazarca', Calnali, MexicoDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United StatesDepartment of Biology, Texas A&M University, College Station, United States; Centro de Investigaciones Científicas de las Huastecas 'Aguazarca', Calnali, MexicoDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, United States; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United StatesHybridization is increasingly being recognized as a common process in both animal and plant species. Negative epistatic interactions between genes from different parental genomes decrease the fitness of hybrids and can limit gene flow between species. However, little is known about the number and genome-wide distribution of genetic incompatibilities separating species. To detect interacting genes, we perform a high-resolution genome scan for linkage disequilibrium between unlinked genomic regions in naturally occurring hybrid populations of swordtail fish. We estimate that hundreds of pairs of genomic regions contribute to reproductive isolation between these species, despite them being recently diverged. Many of these incompatibilities are likely the result of natural or sexual selection on hybrids, since intrinsic isolation is known to be weak. Patterns of genomic divergence at these regions imply that genetic incompatibilities play a significant role in limiting gene flow even in young species.https://elifesciences.org/articles/02535hybridizationspeciationhybrid fitnessgenetic incompatibility |
| spellingShingle | Molly Schumer Rongfeng Cui Daniel L Powell Rebecca Dresner Gil G Rosenthal Peter Andolfatto High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species eLife hybridization speciation hybrid fitness genetic incompatibility |
| title | High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species |
| title_full | High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species |
| title_fullStr | High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species |
| title_full_unstemmed | High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species |
| title_short | High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species |
| title_sort | high resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species |
| topic | hybridization speciation hybrid fitness genetic incompatibility |
| url | https://elifesciences.org/articles/02535 |
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