DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review
The prevalence of breast cancer in young women (YWBC) has increased alarmingly. Significant efforts are being made to elucidate the biological mechanisms concerning the development, prognosis, and pathological response in early-onset breast cancer (BC) patients. Dysfunctional DNA repair proteins are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/13030 |
| _version_ | 1797507701433958400 |
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| author | Laura Keren Urbina-Jara Emmanuel Martinez-Ledesma Augusto Rojas-Martinez Francisco Ricardo Rodriguez-Recio Rocio Ortiz-Lopez |
| author_facet | Laura Keren Urbina-Jara Emmanuel Martinez-Ledesma Augusto Rojas-Martinez Francisco Ricardo Rodriguez-Recio Rocio Ortiz-Lopez |
| author_sort | Laura Keren Urbina-Jara |
| collection | DOAJ |
| description | The prevalence of breast cancer in young women (YWBC) has increased alarmingly. Significant efforts are being made to elucidate the biological mechanisms concerning the development, prognosis, and pathological response in early-onset breast cancer (BC) patients. Dysfunctional DNA repair proteins are implied in BC predisposition, progression, and therapy response, underscoring the need for further analyses on DNA repair genes. Public databases of large patient datasets such as METABRIC, TCGA, COSMIC, and cancer cell lines allow the identification of variants in DNA repair genes and possible precision drug candidates. This study aimed at identifying variants and drug candidates that may benefit Latin American (LA) YWBC. We analyzed pathogenic variants in 90 genes involved in DNA repair in public BC datasets from METABRIC, TCGA, COSMIC, CCLE, and COSMIC Cell Lines Project. Results showed that reported DNA repair germline variants in the LA dataset are underrepresented in large databases, in contrast to other populations. Additionally, only six gene repair variants in women under 50 years old from the study population were reported in BC cell lines. Therefore, there is a need for new approaches to study DNA repair variants reported in young women from LA. |
| first_indexed | 2024-03-10T04:52:11Z |
| format | Article |
| id | doaj.art-4d5030874f434eb19ac4796119be8596 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:11Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4d5030874f434eb19ac4796119be85962023-11-23T02:32:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122231303010.3390/ijms222313030DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic ReviewLaura Keren Urbina-Jara0Emmanuel Martinez-Ledesma1Augusto Rojas-Martinez2Francisco Ricardo Rodriguez-Recio3Rocio Ortiz-Lopez4Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoThe prevalence of breast cancer in young women (YWBC) has increased alarmingly. Significant efforts are being made to elucidate the biological mechanisms concerning the development, prognosis, and pathological response in early-onset breast cancer (BC) patients. Dysfunctional DNA repair proteins are implied in BC predisposition, progression, and therapy response, underscoring the need for further analyses on DNA repair genes. Public databases of large patient datasets such as METABRIC, TCGA, COSMIC, and cancer cell lines allow the identification of variants in DNA repair genes and possible precision drug candidates. This study aimed at identifying variants and drug candidates that may benefit Latin American (LA) YWBC. We analyzed pathogenic variants in 90 genes involved in DNA repair in public BC datasets from METABRIC, TCGA, COSMIC, CCLE, and COSMIC Cell Lines Project. Results showed that reported DNA repair germline variants in the LA dataset are underrepresented in large databases, in contrast to other populations. Additionally, only six gene repair variants in women under 50 years old from the study population were reported in BC cell lines. Therefore, there is a need for new approaches to study DNA repair variants reported in young women from LA.https://www.mdpi.com/1422-0067/22/23/13030DNA repair genesbreast cancer in young womenbreast cancer datasetscell linestherapy |
| spellingShingle | Laura Keren Urbina-Jara Emmanuel Martinez-Ledesma Augusto Rojas-Martinez Francisco Ricardo Rodriguez-Recio Rocio Ortiz-Lopez DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review International Journal of Molecular Sciences DNA repair genes breast cancer in young women breast cancer datasets cell lines therapy |
| title | DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review |
| title_full | DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review |
| title_fullStr | DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review |
| title_full_unstemmed | DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review |
| title_short | DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review |
| title_sort | dna repair genes as drug candidates for early breast cancer onset in latin america a systematic review |
| topic | DNA repair genes breast cancer in young women breast cancer datasets cell lines therapy |
| url | https://www.mdpi.com/1422-0067/22/23/13030 |
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