Pectasol‐C Modified Citrus Pectin targets Galectin‐3‐induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids

Pectasol‐C Modified Citrus Pectin targets Galectin‐3‐induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids

Abstract Here we sought to determine the relationship between STAT3 activity and Galectin‐3 (Gal‐3) and to investigate the cytotoxic effect of PectaSol‐C Modified Citrus Pectin (Pect‐MCP) as a specific competitive inhibitor of Galectin‐3 (Gal‐3) in combination with Paclitaxel (PTX) to kill the ovari...

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Bibliographic Details
Main Authors: Ghamartaj Hossein, Sina Halvaei, Yassaman Heidarian, Zeinab Dehghani‐Ghobadi, Mina Hassani, Homa Hosseini, Nima Naderi, Shahrzad Sheikh Hassani
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Cancer Medicine
Subjects:
Galectin‐3
integrin
invasion
migration
ovarian cancer
STAT3
Online Access:https://doi.org/10.1002/cam4.2334

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