Janus particle-engineered structural lipiodol droplets for arterial embolization
Abstract Embolization (utilizing embolic materials to block blood vessels) has been considered one of the most promising strategies for clinical disease treatments. However, the existing embolic materials have poor embolization effectiveness, posing a great challenge to highly efficient embolization...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41322-6 |
| _version_ | 1827709960486649856 |
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| author | Sijian Tao Bingquan Lin Houwang Zhou Suinan Sha Xiangrong Hao Xuejiao Wang Jianping Chen Yangning Zhang Jiahao Pan Jiabin Xu Junling Zeng Ying Wang Xiaofeng He Jiahao Huang Wei Zhao Jun-Bing Fan |
| author_facet | Sijian Tao Bingquan Lin Houwang Zhou Suinan Sha Xiangrong Hao Xuejiao Wang Jianping Chen Yangning Zhang Jiahao Pan Jiabin Xu Junling Zeng Ying Wang Xiaofeng He Jiahao Huang Wei Zhao Jun-Bing Fan |
| author_sort | Sijian Tao |
| collection | DOAJ |
| description | Abstract Embolization (utilizing embolic materials to block blood vessels) has been considered one of the most promising strategies for clinical disease treatments. However, the existing embolic materials have poor embolization effectiveness, posing a great challenge to highly efficient embolization. In this study, we construct Janus particle-engineered structural lipiodol droplets by programming the self-assembly of Janus particles at the lipiodol-water interface. As a result, we achieve highly efficient renal embolization in rabbits. The obtained structural lipiodol droplets exhibit excellent mechanical stability and viscoelasticity, enabling them to closely pack together to efficiently embolize the feeding artery. They also feature good viscoelastic deformation capacities and can travel distally to embolize finer vasculatures down to 40 μm. After 14 days post-embolization, the Janus particle-engineered structural lipiodol droplets achieve efficient embolization without evidence of recanalization or non-target embolization, exhibiting embolization effectiveness superior to the clinical lipiodol-based emulsion. Our strategy provides an alternative approach to large-scale fabricate embolic materials for highly efficient embolization and exhibits good potential for clinical applications. |
| first_indexed | 2024-03-10T17:30:34Z |
| format | Article |
| id | doaj.art-4d557c1af3db4f90acdc9757e4751a2c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:30:34Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4d557c1af3db4f90acdc9757e4751a2c2023-11-20T10:02:05ZengNature PortfolioNature Communications2041-17232023-09-0114111310.1038/s41467-023-41322-6Janus particle-engineered structural lipiodol droplets for arterial embolizationSijian Tao0Bingquan Lin1Houwang Zhou2Suinan Sha3Xiangrong Hao4Xuejiao Wang5Jianping Chen6Yangning Zhang7Jiahao Pan8Jiabin Xu9Junling Zeng10Ying Wang11Xiaofeng He12Jiahao Huang13Wei Zhao14Jun-Bing Fan15Cancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Medical Imaging Center, Nanfang Hospital, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityDivision of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical UniversityLaboratory Animal Research Center of Nanfang Hospital, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityDivision of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical UniversitySchool of Biomedical Engineering, Southern Medical UniversityDivision of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityAbstract Embolization (utilizing embolic materials to block blood vessels) has been considered one of the most promising strategies for clinical disease treatments. However, the existing embolic materials have poor embolization effectiveness, posing a great challenge to highly efficient embolization. In this study, we construct Janus particle-engineered structural lipiodol droplets by programming the self-assembly of Janus particles at the lipiodol-water interface. As a result, we achieve highly efficient renal embolization in rabbits. The obtained structural lipiodol droplets exhibit excellent mechanical stability and viscoelasticity, enabling them to closely pack together to efficiently embolize the feeding artery. They also feature good viscoelastic deformation capacities and can travel distally to embolize finer vasculatures down to 40 μm. After 14 days post-embolization, the Janus particle-engineered structural lipiodol droplets achieve efficient embolization without evidence of recanalization or non-target embolization, exhibiting embolization effectiveness superior to the clinical lipiodol-based emulsion. Our strategy provides an alternative approach to large-scale fabricate embolic materials for highly efficient embolization and exhibits good potential for clinical applications.https://doi.org/10.1038/s41467-023-41322-6 |
| spellingShingle | Sijian Tao Bingquan Lin Houwang Zhou Suinan Sha Xiangrong Hao Xuejiao Wang Jianping Chen Yangning Zhang Jiahao Pan Jiabin Xu Junling Zeng Ying Wang Xiaofeng He Jiahao Huang Wei Zhao Jun-Bing Fan Janus particle-engineered structural lipiodol droplets for arterial embolization Nature Communications |
| title | Janus particle-engineered structural lipiodol droplets for arterial embolization |
| title_full | Janus particle-engineered structural lipiodol droplets for arterial embolization |
| title_fullStr | Janus particle-engineered structural lipiodol droplets for arterial embolization |
| title_full_unstemmed | Janus particle-engineered structural lipiodol droplets for arterial embolization |
| title_short | Janus particle-engineered structural lipiodol droplets for arterial embolization |
| title_sort | janus particle engineered structural lipiodol droplets for arterial embolization |
| url | https://doi.org/10.1038/s41467-023-41322-6 |
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