Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old
Background and objective With the aging of the population, the incidence of lung cancer in elderly rises. It showed that the incidence and mortality of lung cancer in people over 70 years were increased in the past 10 years. We defined age 70 as boundary line of the elderly patients in lung cancer....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2011-06-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.05 |
| _version_ | 1819155093031747584 |
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| author | Hua ZHENG Li TONG Ying HU Weihua WU Hongmei ZHANG Baolan LI |
| author_facet | Hua ZHENG Li TONG Ying HU Weihua WU Hongmei ZHANG Baolan LI |
| author_sort | Hua ZHENG |
| collection | DOAJ |
| description | Background and objective With the aging of the population, the incidence of lung cancer in elderly rises. It showed that the incidence and mortality of lung cancer in people over 70 years were increased in the past 10 years. We defined age 70 as boundary line of the elderly patients in lung cancer. The aim of this study is to analyze the factors of affecting prognosis. Methods A retrospective study had enrolled 408 cases of lung cancer aged over 70 and SPSS 13.0 software was used in univariate analysis and COX regression analysis to analyze factors affecting prognosis, such as gender, age, complications, symptoms, pathological type, clinical stage, effusion, surgery, radiotherapy, chemotherapy and so on. Results In univariate analysis, symptoms, stage, effusion, surgery, chemotherapy and chemotherapy cycles showed affecting prognosis significantly. In COX regression analysis, it showed that clinical stage (P<0.001), surgery (P=0.013), chemotherapy cycles (P=0.001) were independent prognostic factors. Conclusion Elderly lung cancer patients could be benefit from surgery and adjuvant chemotherapy while early stage. At late stage, their survival time may be prolonged when receive chemotherapy at least 4 cycles. Single-agent chemotherapy would be a good choice for elderly lung cancer. Effusion, particularly, pericardial effusion significantly influenced the prognosis, so that it should be effectively controlled. |
| first_indexed | 2024-12-22T15:31:29Z |
| format | Article |
| id | doaj.art-4d56a8afce5f484da513a12fa3e69585 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-22T15:31:29Z |
| publishDate | 2011-06-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-4d56a8afce5f484da513a12fa3e695852022-12-21T18:21:21ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872011-06-0114650250610.3779/j.issn.1009-3419.2011.06.05Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years OldHua ZHENGLi TONGYing HUWeihua WUHongmei ZHANGBaolan LIBackground and objective With the aging of the population, the incidence of lung cancer in elderly rises. It showed that the incidence and mortality of lung cancer in people over 70 years were increased in the past 10 years. We defined age 70 as boundary line of the elderly patients in lung cancer. The aim of this study is to analyze the factors of affecting prognosis. Methods A retrospective study had enrolled 408 cases of lung cancer aged over 70 and SPSS 13.0 software was used in univariate analysis and COX regression analysis to analyze factors affecting prognosis, such as gender, age, complications, symptoms, pathological type, clinical stage, effusion, surgery, radiotherapy, chemotherapy and so on. Results In univariate analysis, symptoms, stage, effusion, surgery, chemotherapy and chemotherapy cycles showed affecting prognosis significantly. In COX regression analysis, it showed that clinical stage (P<0.001), surgery (P=0.013), chemotherapy cycles (P=0.001) were independent prognostic factors. Conclusion Elderly lung cancer patients could be benefit from surgery and adjuvant chemotherapy while early stage. At late stage, their survival time may be prolonged when receive chemotherapy at least 4 cycles. Single-agent chemotherapy would be a good choice for elderly lung cancer. Effusion, particularly, pericardial effusion significantly influenced the prognosis, so that it should be effectively controlled.http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.05Lung neoplasmsGeriatricsPrognosis |
| spellingShingle | Hua ZHENG Li TONG Ying HU Weihua WU Hongmei ZHANG Baolan LI Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old Chinese Journal of Lung Cancer Lung neoplasms Geriatrics Prognosis |
| title | Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old |
| title_full | Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old |
| title_fullStr | Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old |
| title_full_unstemmed | Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old |
| title_short | Prognostic Factors in 408 Elderly Lung Cancer Patients More than 70 Years Old |
| title_sort | prognostic factors in 408 elderly lung cancer patients more than 70 years old |
| topic | Lung neoplasms Geriatrics Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2011.06.05 |
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