Corneal collagen crosslinking in keratoconus and other eye disease
Keratoconus is a condition characterized by biomechanical instability of the cornea, presenting in a progressive, asymmetric and bilateral way. Corneal collagen crosslinking (CXL) with riboflavin and Ultraviolet-A (UVA) is a new technique of corneal tissue strengthening that combines the use of ribo...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-04-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2015/2/20150235.pdf |
| _version_ | 1818977419655118848 |
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| author | Adel Alhayek Pei-Rong Lu |
| author_facet | Adel Alhayek Pei-Rong Lu |
| author_sort | Adel Alhayek |
| collection | DOAJ |
| description | Keratoconus is a condition characterized by biomechanical instability of the cornea, presenting in a progressive, asymmetric and bilateral way. Corneal collagen crosslinking (CXL) with riboflavin and Ultraviolet-A (UVA) is a new technique of corneal tissue strengthening that combines the use of riboflavin as a photo sensitizer and UVA irradiation. Studies showed that CXL was effective in halting the progression of keratoconus over a period of up to four years. The published studies also revealed a reduction of max K readings by more than 2 D, while the postoperative spherical equivalent (SEQ) was reduced by an average of more than 1 D and refractive cylinder decreased by about 1 D. The major indication for the use of CXL is to inhibit the progression of corneal ecstasies, such as keratoconus and pellucid marginal degeneration. CXL may also be effective in the treatment and prophylaxis of iatrogenic keratectasia, resulting from excessively aggressive photo ablation. This treatment has been used to treat infectious corneal ulcers with apparent favorable results. Most recent studies demonstrate the beneficial impact of CXL for iatrogenic ecstasies, pellucid marginal degeneration, infectious keratitis, bullous keratopathy and ulcerative keratitis. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subject to epithelial debridement and the application of a soft contact lens. Formation of temporary corneal haze, permanent scars, endothelial damage, treatment failure, sterile infiltrates, bullous keratopathy and herpes reactivation are the other reported complications of this procedure. |
| first_indexed | 2024-12-20T16:27:27Z |
| format | Article |
| id | doaj.art-4d56f93ecafe4b48acaa1bb8698b5377 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-20T16:27:27Z |
| publishDate | 2015-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-4d56f93ecafe4b48acaa1bb8698b53772022-12-21T19:33:22ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982015-04-018240741810.3980/j.issn.2222-3959.2015.02.35Corneal collagen crosslinking in keratoconus and other eye diseaseAdel Alhayek0Pei-Rong Lu1Department of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, ChinaKeratoconus is a condition characterized by biomechanical instability of the cornea, presenting in a progressive, asymmetric and bilateral way. Corneal collagen crosslinking (CXL) with riboflavin and Ultraviolet-A (UVA) is a new technique of corneal tissue strengthening that combines the use of riboflavin as a photo sensitizer and UVA irradiation. Studies showed that CXL was effective in halting the progression of keratoconus over a period of up to four years. The published studies also revealed a reduction of max K readings by more than 2 D, while the postoperative spherical equivalent (SEQ) was reduced by an average of more than 1 D and refractive cylinder decreased by about 1 D. The major indication for the use of CXL is to inhibit the progression of corneal ecstasies, such as keratoconus and pellucid marginal degeneration. CXL may also be effective in the treatment and prophylaxis of iatrogenic keratectasia, resulting from excessively aggressive photo ablation. This treatment has been used to treat infectious corneal ulcers with apparent favorable results. Most recent studies demonstrate the beneficial impact of CXL for iatrogenic ecstasies, pellucid marginal degeneration, infectious keratitis, bullous keratopathy and ulcerative keratitis. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subject to epithelial debridement and the application of a soft contact lens. Formation of temporary corneal haze, permanent scars, endothelial damage, treatment failure, sterile infiltrates, bullous keratopathy and herpes reactivation are the other reported complications of this procedure.http://www.ijo.cn/en_publish/2015/2/20150235.pdfkeratoconuscollagencorneal cross-linkingultraviolet radiation and riboflavin |
| spellingShingle | Adel Alhayek Pei-Rong Lu Corneal collagen crosslinking in keratoconus and other eye disease International Journal of Ophthalmology keratoconus collagen corneal cross-linking ultraviolet radiation and riboflavin |
| title | Corneal collagen crosslinking in keratoconus and other eye disease |
| title_full | Corneal collagen crosslinking in keratoconus and other eye disease |
| title_fullStr | Corneal collagen crosslinking in keratoconus and other eye disease |
| title_full_unstemmed | Corneal collagen crosslinking in keratoconus and other eye disease |
| title_short | Corneal collagen crosslinking in keratoconus and other eye disease |
| title_sort | corneal collagen crosslinking in keratoconus and other eye disease |
| topic | keratoconus collagen corneal cross-linking ultraviolet radiation and riboflavin |
| url | http://www.ijo.cn/en_publish/2015/2/20150235.pdf |
| work_keys_str_mv | AT adelalhayek cornealcollagencrosslinkinginkeratoconusandothereyedisease AT peironglu cornealcollagencrosslinkinginkeratoconusandothereyedisease |