Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population
Abstract Background The present study evaluated the predictive ability of five known “best” obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) and visce...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0927-x |
| _version_ | 1818015915370872832 |
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| author | Zhan Gu Ping Zhu Qiao Wang Huayu He Jingjuan Xu Li Zhang Dong Li Jianying Wang Xiaojuan Hu Guang Ji Lei Zhang Baocheng Liu |
| author_facet | Zhan Gu Ping Zhu Qiao Wang Huayu He Jingjuan Xu Li Zhang Dong Li Jianying Wang Xiaojuan Hu Guang Ji Lei Zhang Baocheng Liu |
| author_sort | Zhan Gu |
| collection | DOAJ |
| description | Abstract Background The present study evaluated the predictive ability of five known “best” obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) and visceral adiposity index (VAI), in identifying metabolic syndrome (MetS) in Chinese elderly population. Methods A total of 6722 elderly Chinese subjects (≥60 years) were recruited into our community-based cross-sectional study from April 2015 to July 2017. The anthropometrics, blood pressure, fasting plasma glucose, blood lipid profiles, family history and health-related behaviours were assessed. Results The prevalence of MetS was 40.4% (32.5% in males and 47.2% in females). With the increase in the number of MetS components (from 0 to 5), all the five parameters showed an increase trend in both genders (all P for trend < 0.001). According to receiver operating characteristic curve (ROC) analyses, all the five parameters performed high predictive value in identifying MetS. The statistical significance of the areas under the curves (AUCs) differences suggested that the AUCs of LAP were the greatest among others in both genders (AUCs were 0.897 in males and 0.875 in females). The optimal cut-off values of LAP were 26.35 in males and 31.04 in females. After adjustment for potentially confounding factors, LAP was strongly associated with the odds of having MetS in both genders, and ORs for MetS increased across quartiles using multivariate logistic regression analysis (P < 0.001). Conclusion LAP appeared to be a superior parameter for predicting MetS in both Chinese elderly males and females, better than VAI, TG/HDL-C, WHtR and BMI. |
| first_indexed | 2024-04-14T07:04:40Z |
| format | Article |
| id | doaj.art-4d596569f12c4eacb02e41301bb82fb8 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-14T07:04:40Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-4d596569f12c4eacb02e41301bb82fb82022-12-22T02:06:36ZengBMCLipids in Health and Disease1476-511X2018-12-011711810.1186/s12944-018-0927-xObesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly populationZhan Gu0Ping Zhu1Qiao Wang2Huayu He3Jingjuan Xu4Li Zhang5Dong Li6Jianying Wang7Xiaojuan Hu8Guang Ji9Lei Zhang10Baocheng Liu11Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineSchool of Rehabilitation Science, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineZhangjiang Community Health Service Center of Pudong New DistrictShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineAbstract Background The present study evaluated the predictive ability of five known “best” obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) and visceral adiposity index (VAI), in identifying metabolic syndrome (MetS) in Chinese elderly population. Methods A total of 6722 elderly Chinese subjects (≥60 years) were recruited into our community-based cross-sectional study from April 2015 to July 2017. The anthropometrics, blood pressure, fasting plasma glucose, blood lipid profiles, family history and health-related behaviours were assessed. Results The prevalence of MetS was 40.4% (32.5% in males and 47.2% in females). With the increase in the number of MetS components (from 0 to 5), all the five parameters showed an increase trend in both genders (all P for trend < 0.001). According to receiver operating characteristic curve (ROC) analyses, all the five parameters performed high predictive value in identifying MetS. The statistical significance of the areas under the curves (AUCs) differences suggested that the AUCs of LAP were the greatest among others in both genders (AUCs were 0.897 in males and 0.875 in females). The optimal cut-off values of LAP were 26.35 in males and 31.04 in females. After adjustment for potentially confounding factors, LAP was strongly associated with the odds of having MetS in both genders, and ORs for MetS increased across quartiles using multivariate logistic regression analysis (P < 0.001). Conclusion LAP appeared to be a superior parameter for predicting MetS in both Chinese elderly males and females, better than VAI, TG/HDL-C, WHtR and BMI.http://link.springer.com/article/10.1186/s12944-018-0927-xMetabolic syndromeObesity and lipid-related parametersChinese elderly populationLipid accumulation productVisceral adiposity indexTriglyceride-to-high-density-lipoprotein-cholesterol |
| spellingShingle | Zhan Gu Ping Zhu Qiao Wang Huayu He Jingjuan Xu Li Zhang Dong Li Jianying Wang Xiaojuan Hu Guang Ji Lei Zhang Baocheng Liu Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population Lipids in Health and Disease Metabolic syndrome Obesity and lipid-related parameters Chinese elderly population Lipid accumulation product Visceral adiposity index Triglyceride-to-high-density-lipoprotein-cholesterol |
| title | Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population |
| title_full | Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population |
| title_fullStr | Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population |
| title_full_unstemmed | Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population |
| title_short | Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population |
| title_sort | obesity and lipid related parameters for predicting metabolic syndrome in chinese elderly population |
| topic | Metabolic syndrome Obesity and lipid-related parameters Chinese elderly population Lipid accumulation product Visceral adiposity index Triglyceride-to-high-density-lipoprotein-cholesterol |
| url | http://link.springer.com/article/10.1186/s12944-018-0927-x |
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