Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation
Background Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with ventricular fibrillation of which the origin is not identified after extensive evaluations. Recent studies suggest an association between mitral annulus disjunction (MAD), mitral valve prolapse (MVP), and ventricular...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.025364 |
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| author | Sanne A. Groeneveld Feddo P. Kirkels Maarten J. Cramer Reinder Evertz Kristina H. Haugaa Pieter G. Postema Niek H. J. Prakken Arco J. Teske Arthur A. M. Wilde Birgitta K. Velthuis Robin Nijveldt Rutger J. Hassink |
| author_facet | Sanne A. Groeneveld Feddo P. Kirkels Maarten J. Cramer Reinder Evertz Kristina H. Haugaa Pieter G. Postema Niek H. J. Prakken Arco J. Teske Arthur A. M. Wilde Birgitta K. Velthuis Robin Nijveldt Rutger J. Hassink |
| author_sort | Sanne A. Groeneveld |
| collection | DOAJ |
| description | Background Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with ventricular fibrillation of which the origin is not identified after extensive evaluations. Recent studies suggest an association between mitral annulus disjunction (MAD), mitral valve prolapse (MVP), and ventricular arrhythmias. The prevalence of MAD and MVP in patients with IVF in this regard is not well established. We aimed to explore the prevalence of MAD and MVP in a consecutive cohort of patients with IVF compared with matched controls. Methods and Results In this retrospective, multicenter cohort study, cardiac magnetic resonance images from patients with IVF (ie, negative for ischemia, cardiomyopathy, and channelopathies) and age‐ and sex‐matched control subjects were analyzed for the presence of MAD (≥2 mm) and MVP (>2 mm). In total, 72 patients (mean age 39±14 years, 42% women) and 72 control subjects (mean age 41±11 years, 42% women) were included. MAD in the inferolateral wall was more prevalent in patients with IVF versus healthy controls (7 [11%] versus 1 [1%], P=0.024). MVP was only seen in patients with IVF and not in controls (5 [7%] versus 0 [0%], P=0.016). MAD was observed in both patients with (n=4) and without (n=3) MVP. Conclusions Inferolateral MAD and MVP were significantly more prevalent in patients with IVF compared with healthy controls. The authors advocate that evaluation of the mitral valve region deserves extra attention in the extensive screening of patients with unexplained cardiac arrest. These findings support further exploration of the pathophysiological mechanisms underlying a subset of IVF that associates with MAD and MVP. |
| first_indexed | 2024-04-13T12:57:36Z |
| format | Article |
| id | doaj.art-4d5b12d5eaf043cfa00651a3b388ae93 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T12:57:36Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-4d5b12d5eaf043cfa00651a3b388ae932022-12-22T02:46:01ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-08-01111610.1161/JAHA.121.025364Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular FibrillationSanne A. Groeneveld0Feddo P. Kirkels1Maarten J. Cramer2Reinder Evertz3Kristina H. Haugaa4Pieter G. Postema5Niek H. J. Prakken6Arco J. Teske7Arthur A. M. Wilde8Birgitta K. Velthuis9Robin Nijveldt10Rutger J. Hassink11Department of Cardiology University Medical Center Utrecht Utrecht the NetherlandsDepartment of Cardiology University Medical Center Utrecht Utrecht the NetherlandsDepartment of Cardiology University Medical Center Utrecht Utrecht the NetherlandsDepartment of Cardiology, Radboudumc Nijmegen the NetherlandsProCardio Center for Innovation Department of Cardiology Oslo University Hospital Rikshospitalet Oslo NorwayHeart Center Department of Clinical and Experimental Cardiology Amsterdam UMC, Location AMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam the NetherlandsDepartment of Radiology University Medical Center Groningen Groningen the NetherlandsDepartment of Cardiology University Medical Center Utrecht Utrecht the NetherlandsHeart Center Department of Clinical and Experimental Cardiology Amsterdam UMC, Location AMC University of Amsterdam Amsterdam Cardiovascular Sciences Amsterdam the NetherlandsDepartment of Radiology University Medical Center Utrecht Utrecht the NetherlandsDepartment of Cardiology, Radboudumc Nijmegen the NetherlandsDepartment of Cardiology University Medical Center Utrecht Utrecht the NetherlandsBackground Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with ventricular fibrillation of which the origin is not identified after extensive evaluations. Recent studies suggest an association between mitral annulus disjunction (MAD), mitral valve prolapse (MVP), and ventricular arrhythmias. The prevalence of MAD and MVP in patients with IVF in this regard is not well established. We aimed to explore the prevalence of MAD and MVP in a consecutive cohort of patients with IVF compared with matched controls. Methods and Results In this retrospective, multicenter cohort study, cardiac magnetic resonance images from patients with IVF (ie, negative for ischemia, cardiomyopathy, and channelopathies) and age‐ and sex‐matched control subjects were analyzed for the presence of MAD (≥2 mm) and MVP (>2 mm). In total, 72 patients (mean age 39±14 years, 42% women) and 72 control subjects (mean age 41±11 years, 42% women) were included. MAD in the inferolateral wall was more prevalent in patients with IVF versus healthy controls (7 [11%] versus 1 [1%], P=0.024). MVP was only seen in patients with IVF and not in controls (5 [7%] versus 0 [0%], P=0.016). MAD was observed in both patients with (n=4) and without (n=3) MVP. Conclusions Inferolateral MAD and MVP were significantly more prevalent in patients with IVF compared with healthy controls. The authors advocate that evaluation of the mitral valve region deserves extra attention in the extensive screening of patients with unexplained cardiac arrest. These findings support further exploration of the pathophysiological mechanisms underlying a subset of IVF that associates with MAD and MVP.https://www.ahajournals.org/doi/10.1161/JAHA.121.025364cardiac magnetic resonance imagingidiopathic ventricular fibrillationmitral annulus disjunctionmitral valve prolapseventricular arrhythmias |
| spellingShingle | Sanne A. Groeneveld Feddo P. Kirkels Maarten J. Cramer Reinder Evertz Kristina H. Haugaa Pieter G. Postema Niek H. J. Prakken Arco J. Teske Arthur A. M. Wilde Birgitta K. Velthuis Robin Nijveldt Rutger J. Hassink Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiac magnetic resonance imaging idiopathic ventricular fibrillation mitral annulus disjunction mitral valve prolapse ventricular arrhythmias |
| title | Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation |
| title_full | Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation |
| title_fullStr | Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation |
| title_full_unstemmed | Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation |
| title_short | Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation |
| title_sort | prevalence of mitral annulus disjunction and mitral valve prolapse in patients with idiopathic ventricular fibrillation |
| topic | cardiac magnetic resonance imaging idiopathic ventricular fibrillation mitral annulus disjunction mitral valve prolapse ventricular arrhythmias |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.025364 |
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