Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae)
Our taxonomic interest in the Neoraputia stimulated an investigation of N. paraensis searching for alkaloids. Fractions were monitored by ¹H NMR and ESI-MS/MS and only those which showed features of anthranilate alkaloids and flavonoids absent in the previous investigations were examined. Stems affo...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2003-01-01
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| Series: | Journal of the Brazilian Chemical Society |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300007 |
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| author | Moraes Valéria R. de S. Tomazela Daniela M. Ferracin Ricardo J. Garcia Cleverson F. Sannomiya Míriam Soriano M. del Pilar C. Silva M. Fátima das G. F. da Vieira Paulo C. Fernandes João B. Rodrigues Filho Edson Magalhães Eva G. Magalhães Aderbal F. Pimenta Eli F. Souza Dulce H. F. de Oliva Glaucius |
| author_facet | Moraes Valéria R. de S. Tomazela Daniela M. Ferracin Ricardo J. Garcia Cleverson F. Sannomiya Míriam Soriano M. del Pilar C. Silva M. Fátima das G. F. da Vieira Paulo C. Fernandes João B. Rodrigues Filho Edson Magalhães Eva G. Magalhães Aderbal F. Pimenta Eli F. Souza Dulce H. F. de Oliva Glaucius |
| author_sort | Moraes Valéria R. de S. |
| collection | DOAJ |
| description | Our taxonomic interest in the Neoraputia stimulated an investigation of N. paraensis searching for alkaloids. Fractions were monitored by ¹H NMR and ESI-MS/MS and only those which showed features of anthranilate alkaloids and flavonoids absent in the previous investigations were examined. Stems afforded the alkaloids flindersine, skimmianine, 8-methoxyflindersine and dictamnine; leaves yielded 3',4',7,8-tetramethoxy-5,6-(2",2"-dimethylpyrano)-flavone, 3',4',5,7,8-pentamethoxyflavone, 5-hydroxy-3',4',6,7-tetramethoxyflavone, 3',4'-methylenedioxy-5,6,7-trimethoxyflavone and 5-hydroxy-3',4'-methylenedioxy-6,7-dimethoxyflavone. The alkaloids have remained undiscovered for 10 years. A number of flavonoids isolated from N. paraensis, N. magnifica, Murraya paniculata, Citrus sinensis graft (Rutaceae), Lonchocarpus montanus (Leguminosae) were evaluated for their ability to inhibit the enzymatic activity of the protein glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi. Highly oxygenated flavones and isoflavone were the most actives. |
| first_indexed | 2024-04-12T10:58:52Z |
| format | Article |
| id | doaj.art-4d5b8c1a4c464adf85735d591c1485fd |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-04-12T10:58:52Z |
| publishDate | 2003-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-4d5b8c1a4c464adf85735d591c1485fd2022-12-22T03:36:00ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532003-01-01143380387Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae)Moraes Valéria R. de S.Tomazela Daniela M.Ferracin Ricardo J.Garcia Cleverson F.Sannomiya MíriamSoriano M. del Pilar C.Silva M. Fátima das G. F. daVieira Paulo C.Fernandes João B.Rodrigues Filho EdsonMagalhães Eva G.Magalhães Aderbal F.Pimenta Eli F.Souza Dulce H. F. deOliva GlauciusOur taxonomic interest in the Neoraputia stimulated an investigation of N. paraensis searching for alkaloids. Fractions were monitored by ¹H NMR and ESI-MS/MS and only those which showed features of anthranilate alkaloids and flavonoids absent in the previous investigations were examined. Stems afforded the alkaloids flindersine, skimmianine, 8-methoxyflindersine and dictamnine; leaves yielded 3',4',7,8-tetramethoxy-5,6-(2",2"-dimethylpyrano)-flavone, 3',4',5,7,8-pentamethoxyflavone, 5-hydroxy-3',4',6,7-tetramethoxyflavone, 3',4'-methylenedioxy-5,6,7-trimethoxyflavone and 5-hydroxy-3',4'-methylenedioxy-6,7-dimethoxyflavone. The alkaloids have remained undiscovered for 10 years. A number of flavonoids isolated from N. paraensis, N. magnifica, Murraya paniculata, Citrus sinensis graft (Rutaceae), Lonchocarpus montanus (Leguminosae) were evaluated for their ability to inhibit the enzymatic activity of the protein glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi. Highly oxygenated flavones and isoflavone were the most actives.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300007RutaceaeLeguminosaeNeoraputiaMurrayaCitrusLonchocarpusTrypanosoma cruzialkaloidflavonoidschemosystematic |
| spellingShingle | Moraes Valéria R. de S. Tomazela Daniela M. Ferracin Ricardo J. Garcia Cleverson F. Sannomiya Míriam Soriano M. del Pilar C. Silva M. Fátima das G. F. da Vieira Paulo C. Fernandes João B. Rodrigues Filho Edson Magalhães Eva G. Magalhães Aderbal F. Pimenta Eli F. Souza Dulce H. F. de Oliva Glaucius Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae) Journal of the Brazilian Chemical Society Rutaceae Leguminosae Neoraputia Murraya Citrus Lonchocarpus Trypanosoma cruzi alkaloid flavonoids chemosystematic |
| title | Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae) |
| title_full | Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae) |
| title_fullStr | Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae) |
| title_full_unstemmed | Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae) |
| title_short | Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae) |
| title_sort | enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in neoraputia rutaceae |
| topic | Rutaceae Leguminosae Neoraputia Murraya Citrus Lonchocarpus Trypanosoma cruzi alkaloid flavonoids chemosystematic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300007 |
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