Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis
AimTo investigate the interactions between the graft-to-recipient weight ratio (GWRWR) and other risk factors responsible for inferior allograft outcomes.MethodsA total of 362 patients who received liver transplantation (LT) were enrolled. Indicators such as graft/recipient weight and other prognost...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1075845/full |
| _version_ | 1797951372625182720 |
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| author | Zhengtao Liu Zhengtao Liu Zhengtao Liu Zhengtao Liu Jingting Lyu Xiang Li Xiang Li Lu Yu Lu Yu Shuping Que Jun Xu Jun Xu Lei Geng Lei Geng Shusen Zheng Shusen Zheng Shusen Zheng Shusen Zheng Shusen Zheng |
| author_facet | Zhengtao Liu Zhengtao Liu Zhengtao Liu Zhengtao Liu Jingting Lyu Xiang Li Xiang Li Lu Yu Lu Yu Shuping Que Jun Xu Jun Xu Lei Geng Lei Geng Shusen Zheng Shusen Zheng Shusen Zheng Shusen Zheng Shusen Zheng |
| author_sort | Zhengtao Liu |
| collection | DOAJ |
| description | AimTo investigate the interactions between the graft-to-recipient weight ratio (GWRWR) and other risk factors responsible for inferior allograft outcomes.MethodsA total of 362 patients who received liver transplantation (LT) were enrolled. Indicators such as graft/recipient weight and other prognostic factors were collected. Comparisons of indicators and survival analysis were performed in groups categorized by the GWRWR. Interactions of large-for-size grafts (LFSGs) with graft macrosteatosis (MaS) were evaluated in terms of relative excess risk caused by interaction (RERI) and attributable proportion (AP). Cytoscape visualized the role of LFSGs in the risk profile for poor prognosis.ResultsBased on the GWRWR, LT cases can be categorized into three subgroups, standard (1%–2.5%), optimal (2.5%–3.0%), and inferior prognosis (>3.0%). Survival analysis confirmed clear separations in cases categorized by the above-defined limits on the GWRWR (P < 0.05). LFSGs caused inferior prognosis by initiating positive interactions with MaS severity.ConclusionThe GWRWR exerted nonlinear effects on prognosis in deceased donor LT cases. LFSGs (GWRWR > 3.0%) caused inferior outcomes, while grafts sized within (2.5%–3.0%) had optimal post-transplant prognosis. MaS increased the risk of poor prognosis by exerting positive synergistic effects on LFSGs. |
| first_indexed | 2024-04-10T22:30:38Z |
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| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-10T22:30:38Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-4d5c5a923bd947229e25484075fa03d42023-01-17T05:53:15ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-01-01910.3389/fsurg.2022.10758451075845Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosisZhengtao Liu0Zhengtao Liu1Zhengtao Liu2Zhengtao Liu3Jingting Lyu4Xiang Li5Xiang Li6Lu Yu7Lu Yu8Shuping Que9Jun Xu10Jun Xu11Lei Geng12Lei Geng13Shusen Zheng14Shusen Zheng15Shusen Zheng16Shusen Zheng17Shusen Zheng18Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Organ Transplantation, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaShulan (Hangzhou) Hospital, Hangzhou, ChinaShulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaShulan (Hangzhou) Hospital, Hangzhou, ChinaSchool of Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDingXiang Clinics, Hangzhou, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaShulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Organ Transplantation, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaShulan (Hangzhou) Hospital, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaAimTo investigate the interactions between the graft-to-recipient weight ratio (GWRWR) and other risk factors responsible for inferior allograft outcomes.MethodsA total of 362 patients who received liver transplantation (LT) were enrolled. Indicators such as graft/recipient weight and other prognostic factors were collected. Comparisons of indicators and survival analysis were performed in groups categorized by the GWRWR. Interactions of large-for-size grafts (LFSGs) with graft macrosteatosis (MaS) were evaluated in terms of relative excess risk caused by interaction (RERI) and attributable proportion (AP). Cytoscape visualized the role of LFSGs in the risk profile for poor prognosis.ResultsBased on the GWRWR, LT cases can be categorized into three subgroups, standard (1%–2.5%), optimal (2.5%–3.0%), and inferior prognosis (>3.0%). Survival analysis confirmed clear separations in cases categorized by the above-defined limits on the GWRWR (P < 0.05). LFSGs caused inferior prognosis by initiating positive interactions with MaS severity.ConclusionThe GWRWR exerted nonlinear effects on prognosis in deceased donor LT cases. LFSGs (GWRWR > 3.0%) caused inferior outcomes, while grafts sized within (2.5%–3.0%) had optimal post-transplant prognosis. MaS increased the risk of poor prognosis by exerting positive synergistic effects on LFSGs.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1075845/fullGWRWRprognosisgraft failureliver transplantationmacrosteatosis |
| spellingShingle | Zhengtao Liu Zhengtao Liu Zhengtao Liu Zhengtao Liu Jingting Lyu Xiang Li Xiang Li Lu Yu Lu Yu Shuping Que Jun Xu Jun Xu Lei Geng Lei Geng Shusen Zheng Shusen Zheng Shusen Zheng Shusen Zheng Shusen Zheng Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis Frontiers in Surgery GWRWR prognosis graft failure liver transplantation macrosteatosis |
| title | Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis |
| title_full | Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis |
| title_fullStr | Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis |
| title_full_unstemmed | Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis |
| title_short | Graft-to-recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis |
| title_sort | graft to recipient weight ratio exerts nonlinear effects on prognosis by interacting with donor liver macrosteatosis |
| topic | GWRWR prognosis graft failure liver transplantation macrosteatosis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1075845/full |
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