Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province
Abstract Background Pharmacogenomics plays a crucial role in individualized therapy, but the variant information of pharmacogenomics in the Dai population is limited. We therefore aimed to screen very important pharmacogenetic (VIP) in the Dai population and compared differences between Dai and othe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-07-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.1231 |
| _version_ | 1831670793639034880 |
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| author | Yujing Cheng Run Dai Wanlu Chen Qi Li Chan Zhang Tonghua Yang |
| author_facet | Yujing Cheng Run Dai Wanlu Chen Qi Li Chan Zhang Tonghua Yang |
| author_sort | Yujing Cheng |
| collection | DOAJ |
| description | Abstract Background Pharmacogenomics plays a crucial role in individualized therapy, but the variant information of pharmacogenomics in the Dai population is limited. We therefore aimed to screen very important pharmacogenetic (VIP) in the Dai population and compared differences between Dai and other 25 populations. Methods In this study, we genotyped 73 VIP variants from the PharmGKB and compared genotype distribution of variants in Dai with other 25 populations by χ2 test. To assess the genetic relationship among 26 populations, we performed the structure analysis. In addition, pair‐wise F‐statistics (Fst) was calculated to measure the population differentiation. Results We found 12, 10, 13, 17, 11, 39, 46, 46, 45, 43, 49, 46, 46, 46, 49, 45, 41, 42, 48, 53, 45, 50, 50, 51, 47, and 50 significantly different variants in Dai compared with other 25 populations. Genetic structure analysis showed Dai had close relationships with CDX (Chinese Dai in Xishuangbanna), CHB (Han Chinese in Beijing), JPT (Japanese in Tokyo), and KHV (Kinh in Ho Chi Minh City, Vietnam). Moreover, Dai is the most similar to KHV according to Fst analysis. Conclusions Our study complement the pharmacogenomics information of Dai population from Yunnan province and provide a theoretical basis for personalized medicine. |
| first_indexed | 2024-12-19T23:23:06Z |
| format | Article |
| id | doaj.art-4d5c7e202f3c45a6afff17073efeb72f |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-12-19T23:23:06Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-4d5c7e202f3c45a6afff17073efeb72f2022-12-21T20:01:54ZengWileyMolecular Genetics & Genomic Medicine2324-92692020-07-0187n/an/a10.1002/mgg3.1231Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan provinceYujing Cheng0Run Dai1Wanlu Chen2Qi Li3Chan Zhang4Tonghua Yang5Department of Blood Transfusion The First People’s Hospital of Yunnan Province Yunnan Province Kunming ChinaDepartment of Blood Transfusion The First People’s Hospital of Yunnan Province Yunnan Province Kunming ChinaDepartment of Blood Transfusion The First People’s Hospital of Yunnan Province Yunnan Province Kunming ChinaDepartment of Blood Transfusion The First People’s Hospital of Yunnan Province Yunnan Province Kunming ChinaDepartment of Blood Transfusion The First People’s Hospital of Yunnan Province Yunnan Province Kunming ChinaDepartment of Hematology The First People’s Hospital of Yunnan Province Yunnan Province Kunming ChinaAbstract Background Pharmacogenomics plays a crucial role in individualized therapy, but the variant information of pharmacogenomics in the Dai population is limited. We therefore aimed to screen very important pharmacogenetic (VIP) in the Dai population and compared differences between Dai and other 25 populations. Methods In this study, we genotyped 73 VIP variants from the PharmGKB and compared genotype distribution of variants in Dai with other 25 populations by χ2 test. To assess the genetic relationship among 26 populations, we performed the structure analysis. In addition, pair‐wise F‐statistics (Fst) was calculated to measure the population differentiation. Results We found 12, 10, 13, 17, 11, 39, 46, 46, 45, 43, 49, 46, 46, 46, 49, 45, 41, 42, 48, 53, 45, 50, 50, 51, 47, and 50 significantly different variants in Dai compared with other 25 populations. Genetic structure analysis showed Dai had close relationships with CDX (Chinese Dai in Xishuangbanna), CHB (Han Chinese in Beijing), JPT (Japanese in Tokyo), and KHV (Kinh in Ho Chi Minh City, Vietnam). Moreover, Dai is the most similar to KHV according to Fst analysis. Conclusions Our study complement the pharmacogenomics information of Dai population from Yunnan province and provide a theoretical basis for personalized medicine.https://doi.org/10.1002/mgg3.1231Daigenetic polymorphismspopulationsvery important pharmacogenetic |
| spellingShingle | Yujing Cheng Run Dai Wanlu Chen Qi Li Chan Zhang Tonghua Yang Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province Molecular Genetics & Genomic Medicine Dai genetic polymorphisms populations very important pharmacogenetic |
| title | Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province |
| title_full | Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province |
| title_fullStr | Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province |
| title_full_unstemmed | Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province |
| title_short | Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province |
| title_sort | genetic polymorphisms of pharmacogenomic vip variants in the dai population from yunnan province |
| topic | Dai genetic polymorphisms populations very important pharmacogenetic |
| url | https://doi.org/10.1002/mgg3.1231 |
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