Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation
Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the a...
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MDPI AG
2020-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/16/3592 |
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| author | Aneta Ostróżka-Cieślik Barbara Dolińska Florian Ryszka |
| author_facet | Aneta Ostróżka-Cieślik Barbara Dolińska Florian Ryszka |
| author_sort | Aneta Ostróżka-Cieślik |
| collection | DOAJ |
| description | Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol<sup>®</sup> (modified Biolasol<sup>®</sup>), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se<sup>4+</sup> ions at a dose of 1 µg/L into the Biolasol<sup>®</sup> preservation solution in the form of Na<sub>2</sub>SeO<sub>3</sub> caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se<sup>4+</sup> on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol<sup>®</sup> modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO<sub>3</sub><sup>2−</sup>) during ischemia/reperfusion. |
| first_indexed | 2024-03-10T17:48:46Z |
| format | Article |
| id | doaj.art-4d5cf786e6fb4d228cb2fbf4db0be8c2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T17:48:46Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4d5cf786e6fb4d228cb2fbf4db0be8c22023-11-20T09:25:01ZengMDPI AGMolecules1420-30492020-08-012516359210.3390/molecules25163592Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney TransplantationAneta Ostróżka-Cieślik0Barbara Dolińska1Florian Ryszka2Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland“Biochefa” Pharmaceutical Research and Production Plant, Kasztanowa 3, 41-200 Sosnowiec, PolandSelenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol<sup>®</sup> (modified Biolasol<sup>®</sup>), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se<sup>4+</sup> ions at a dose of 1 µg/L into the Biolasol<sup>®</sup> preservation solution in the form of Na<sub>2</sub>SeO<sub>3</sub> caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se<sup>4+</sup> on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol<sup>®</sup> modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO<sub>3</sub><sup>2−</sup>) during ischemia/reperfusion.https://www.mdpi.com/1420-3049/25/16/3592seleniumprolactinorgan preservation solutionBiolasol<sup>®</sup>kidney transplantation |
| spellingShingle | Aneta Ostróżka-Cieślik Barbara Dolińska Florian Ryszka Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation Molecules selenium prolactin organ preservation solution Biolasol<sup>®</sup> kidney transplantation |
| title | Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation |
| title_full | Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation |
| title_fullStr | Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation |
| title_full_unstemmed | Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation |
| title_short | Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation |
| title_sort | therapeutic potential of selenium as a component of preservation solutions for kidney transplantation |
| topic | selenium prolactin organ preservation solution Biolasol<sup>®</sup> kidney transplantation |
| url | https://www.mdpi.com/1420-3049/25/16/3592 |
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