Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts
The creation of small-diameter tissue-engineered vascular grafts using biodegradable materials has the potential to change the quality of cardiovascular surgery in the future. The implantation of these tissue-engineered arterial grafts has yet to reach clinical application. One of the reasons for th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/10/4563 |
| _version_ | 1797533810222432256 |
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| author | Yuichi Matsuzaki Anudari Ulziibayar Toshihiro Shoji Toshiharu Shinoka |
| author_facet | Yuichi Matsuzaki Anudari Ulziibayar Toshihiro Shoji Toshiharu Shinoka |
| author_sort | Yuichi Matsuzaki |
| collection | DOAJ |
| description | The creation of small-diameter tissue-engineered vascular grafts using biodegradable materials has the potential to change the quality of cardiovascular surgery in the future. The implantation of these tissue-engineered arterial grafts has yet to reach clinical application. One of the reasons for this is thrombus occlusion of the graft in the acute phase. In this paper, we first describe the causes of accelerated thrombus formation and discuss the drugs that are thought to inhibit thrombus formation. We then review the latest research on methods to locally bind the anticoagulant heparin to biodegradable materials and methods to extend the duration of sustained heparin release. We also discuss the results of studies using large animal models and the challenges that need to be overcome for future clinical applications. |
| first_indexed | 2024-03-10T11:20:55Z |
| format | Article |
| id | doaj.art-4d5d2269cfb64b7b8e990d9931ba71e1 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:20:55Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-4d5d2269cfb64b7b8e990d9931ba71e12023-11-21T20:04:32ZengMDPI AGApplied Sciences2076-34172021-05-011110456310.3390/app11104563Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular GraftsYuichi Matsuzaki0Anudari Ulziibayar1Toshihiro Shoji2Toshiharu Shinoka3Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USACenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USACenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USACenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USAThe creation of small-diameter tissue-engineered vascular grafts using biodegradable materials has the potential to change the quality of cardiovascular surgery in the future. The implantation of these tissue-engineered arterial grafts has yet to reach clinical application. One of the reasons for this is thrombus occlusion of the graft in the acute phase. In this paper, we first describe the causes of accelerated thrombus formation and discuss the drugs that are thought to inhibit thrombus formation. We then review the latest research on methods to locally bind the anticoagulant heparin to biodegradable materials and methods to extend the duration of sustained heparin release. We also discuss the results of studies using large animal models and the challenges that need to be overcome for future clinical applications.https://www.mdpi.com/2076-3417/11/10/4563tissue-engineered vascular graftsbiodegradable materialanticoagulationmedicationheparinlarge-animal study |
| spellingShingle | Yuichi Matsuzaki Anudari Ulziibayar Toshihiro Shoji Toshiharu Shinoka Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts Applied Sciences tissue-engineered vascular grafts biodegradable material anticoagulation medication heparin large-animal study |
| title | Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts |
| title_full | Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts |
| title_fullStr | Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts |
| title_full_unstemmed | Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts |
| title_short | Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts |
| title_sort | heparin eluting tissue engineered bioabsorbable vascular grafts |
| topic | tissue-engineered vascular grafts biodegradable material anticoagulation medication heparin large-animal study |
| url | https://www.mdpi.com/2076-3417/11/10/4563 |
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