The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment
Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor that originates from the biliary system. With restricted treatment options at hand, the challenging aspect of early CCA diagnosis leads to a bleak prognosis. Besides the intrinsic characteristics of tumor cells, the generation and progr...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1336685/full |
| _version_ | 1827385778676695040 |
|---|---|
| author | Nuoqi Zhang Lizhuang Shu Zengli Liu Zengli Liu Anda Shi Liming Zhao Shaohui Huang Guoli Sheng Zhangdi Yan Yan Song Fan Huang Yongchang Tang Zongli Zhang |
| author_facet | Nuoqi Zhang Lizhuang Shu Zengli Liu Zengli Liu Anda Shi Liming Zhao Shaohui Huang Guoli Sheng Zhangdi Yan Yan Song Fan Huang Yongchang Tang Zongli Zhang |
| author_sort | Nuoqi Zhang |
| collection | DOAJ |
| description | Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor that originates from the biliary system. With restricted treatment options at hand, the challenging aspect of early CCA diagnosis leads to a bleak prognosis. Besides the intrinsic characteristics of tumor cells, the generation and progression of CCA are profoundly influenced by the tumor microenvironment, which engages in intricate interactions with cholangiocarcinoma cells. Of notable significance is the role of extracellular vesicles as key carriers in enabling communication between cancer cells and the tumor microenvironment. This review aims to provide a comprehensive overview of current research examining the interplay between extracellular vesicles and the tumor microenvironment in the context of CCA. Specifically, we will emphasize the significant contributions of extracellular vesicles in molding the CCA microenvironment and explore their potential applications in the diagnosis, prognosis assessment, and therapeutic strategies for this aggressive malignancy. |
| first_indexed | 2024-03-08T15:31:30Z |
| format | Article |
| id | doaj.art-4d5d6a44e4be4b15b11421cf2e949693 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T15:31:30Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4d5d6a44e4be4b15b11421cf2e9496932024-01-10T04:18:51ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011410.3389/fphar.2023.13366851336685The role of extracellular vesicles in cholangiocarcinoma tumor microenvironmentNuoqi Zhang0Lizhuang Shu1Zengli Liu2Zengli Liu3Anda Shi4Liming Zhao5Shaohui Huang6Guoli Sheng7Zhangdi Yan8Yan Song9Fan Huang10Yongchang Tang11Zongli Zhang12Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Qingdao, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, ChinaCholangiocarcinoma (CCA) is a highly aggressive malignant tumor that originates from the biliary system. With restricted treatment options at hand, the challenging aspect of early CCA diagnosis leads to a bleak prognosis. Besides the intrinsic characteristics of tumor cells, the generation and progression of CCA are profoundly influenced by the tumor microenvironment, which engages in intricate interactions with cholangiocarcinoma cells. Of notable significance is the role of extracellular vesicles as key carriers in enabling communication between cancer cells and the tumor microenvironment. This review aims to provide a comprehensive overview of current research examining the interplay between extracellular vesicles and the tumor microenvironment in the context of CCA. Specifically, we will emphasize the significant contributions of extracellular vesicles in molding the CCA microenvironment and explore their potential applications in the diagnosis, prognosis assessment, and therapeutic strategies for this aggressive malignancy.https://www.frontiersin.org/articles/10.3389/fphar.2023.1336685/fullcholangiocarcinomatumor microenvironmentextracellular vesiclesexosomeEV-based therapy |
| spellingShingle | Nuoqi Zhang Lizhuang Shu Zengli Liu Zengli Liu Anda Shi Liming Zhao Shaohui Huang Guoli Sheng Zhangdi Yan Yan Song Fan Huang Yongchang Tang Zongli Zhang The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment Frontiers in Pharmacology cholangiocarcinoma tumor microenvironment extracellular vesicles exosome EV-based therapy |
| title | The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment |
| title_full | The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment |
| title_fullStr | The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment |
| title_full_unstemmed | The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment |
| title_short | The role of extracellular vesicles in cholangiocarcinoma tumor microenvironment |
| title_sort | role of extracellular vesicles in cholangiocarcinoma tumor microenvironment |
| topic | cholangiocarcinoma tumor microenvironment extracellular vesicles exosome EV-based therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1336685/full |
| work_keys_str_mv | AT nuoqizhang theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT lizhuangshu theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zengliliu theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zengliliu theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT andashi theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT limingzhao theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT shaohuihuang theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT guolisheng theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zhangdiyan theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT yansong theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT fanhuang theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT yongchangtang theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zonglizhang theroleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT nuoqizhang roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT lizhuangshu roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zengliliu roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zengliliu roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT andashi roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT limingzhao roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT shaohuihuang roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT guolisheng roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zhangdiyan roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT yansong roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT fanhuang roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT yongchangtang roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment AT zonglizhang roleofextracellularvesiclesincholangiocarcinomatumormicroenvironment |