Cellular mechanotransduction
Cell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions.&am...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2016-01-01
|
| Series: | AIMS Biophysics |
| Subjects: | |
| Online Access: | http://www.aimspress.com/biophysics/article/611/fulltext.html |
| _version_ | 1818013531591671808 |
|---|---|
| author | Wolfgang H. Goldmann José Luis Alonso |
| author_facet | Wolfgang H. Goldmann José Luis Alonso |
| author_sort | Wolfgang H. Goldmann |
| collection | DOAJ |
| description | Cell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions. Adherent cells are anchored <em>via</em> focal adhesions (FAs) to the extracellular matrix, while cell-cell contacts are connected <em>via</em> focal adherens junctions (FAJs). Force transmission over considerable distances and stress focusing at these adhesion sites make them prime candidates for mechanosensors. Exactly which protein(s) within FAs and FAJs or which membrane component of ion channels sense, transmit, and respond to mechano-chemical signaling is currently strongly debated and numerous candidates have been proposed. |
| first_indexed | 2024-04-14T06:34:23Z |
| format | Article |
| id | doaj.art-4d5da62bd89b43c9a66a6a89e68873c7 |
| institution | Directory Open Access Journal |
| issn | 2377-9098 |
| language | English |
| last_indexed | 2024-04-14T06:34:23Z |
| publishDate | 2016-01-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Biophysics |
| spelling | doaj.art-4d5da62bd89b43c9a66a6a89e68873c72022-12-22T02:07:31ZengAIMS PressAIMS Biophysics2377-90982016-01-0131506210.3934/biophy.2016.1.50biophy-03-00050Cellular mechanotransductionWolfgang H. Goldmann0José Luis Alonso1Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, GermanDept. of Medicine, Mass. General Hospital/Harvard Medical School, Charlestown, MA 02129 USCell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions. Adherent cells are anchored <em>via</em> focal adhesions (FAs) to the extracellular matrix, while cell-cell contacts are connected <em>via</em> focal adherens junctions (FAJs). Force transmission over considerable distances and stress focusing at these adhesion sites make them prime candidates for mechanosensors. Exactly which protein(s) within FAs and FAJs or which membrane component of ion channels sense, transmit, and respond to mechano-chemical signaling is currently strongly debated and numerous candidates have been proposed.http://www.aimspress.com/biophysics/article/611/fulltext.htmlintegrinsfocal adhesionscell-matrix and cell-cell contactsmechanosensingmechanotransduction |
| spellingShingle | Wolfgang H. Goldmann José Luis Alonso Cellular mechanotransduction AIMS Biophysics integrins focal adhesions cell-matrix and cell-cell contacts mechanosensing mechanotransduction |
| title | Cellular mechanotransduction |
| title_full | Cellular mechanotransduction |
| title_fullStr | Cellular mechanotransduction |
| title_full_unstemmed | Cellular mechanotransduction |
| title_short | Cellular mechanotransduction |
| title_sort | cellular mechanotransduction |
| topic | integrins focal adhesions cell-matrix and cell-cell contacts mechanosensing mechanotransduction |
| url | http://www.aimspress.com/biophysics/article/611/fulltext.html |
| work_keys_str_mv | AT wolfganghgoldmann cellularmechanotransduction AT joseluisalonso cellularmechanotransduction |