Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China
Li Yu, Yu-Hong Deng, Yuan-Hui Huang, Hai-Jin Ke, Yong Guo, Jie-Ling Wu Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Jie-Ling Wu; Yong GuoDepartment of Chi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-05-01
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| Series: | Journal of Asthma and Allergy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/comparison-of-gut-microbiota-between-infants-with-atopic-dermatitis-an-peer-reviewed-fulltext-article-JAA |
| _version_ | 1818733402520551424 |
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| author | Yu L Deng YH Huang YH Ke HJ Guo Y Wu JL |
| author_facet | Yu L Deng YH Huang YH Ke HJ Guo Y Wu JL |
| author_sort | Yu L |
| collection | DOAJ |
| description | Li Yu, Yu-Hong Deng, Yuan-Hui Huang, Hai-Jin Ke, Yong Guo, Jie-Ling Wu Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Jie-Ling Wu; Yong GuoDepartment of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, 511400, Guangdong, People’s Republic of ChinaTel +86 20 39151521Email jieling3861@163.com; geyong084@163.comPurpose: Evidence on the role of the gut microbiota in atopic dermatitis is inconsistent as human intestinal microbiota is influenced by geography. This cross-sectional study therefore aimed to compare differences in the gut microbiota of infants with atopic dermatitis and healthy infants in Guangzhou, China, by analyzing their stool.Patients and Methods: The composition of the intestinal microbiota was analyzed from the stool samples of 20 infants with atopic dermatitis (AD group) and 25 healthy infants (non-AD group) (1– 6 months old), using full-length 16S rRNA gene sequencing. The Wilcoxon test was used to analyze the relative abundance of bacteria by phylum, family, genus, and species between groups; microbial community richness and diversity were compared between the two groups.Results: There were no significant differences in the microbial community richness and diversity between the two groups. At the phylum level, 11 bacterial phyla were found; most sequences belonged to one of the three dominant bacterial phyla – Firmicutes, Proteobacteria, and Bacteroidetes. The top 10 microbes at the phylum, family, and genus levels showed no significant changes in their composition within the gut microbiota between the AD and non-AD groups. A decrease in the ratio of the Streptococcus genus was found in atopic dermatitis group when compared with healthy controls (p=0.048).Conclusion: A decrease in the abundance of Streptococcus was found in children with AD. The role of Streptococcus in the development of AD needs to be confirmed in a large cohort study.Keywords: allergy, infant, gut microbiome, Streptococcus |
| first_indexed | 2024-12-17T23:48:54Z |
| format | Article |
| id | doaj.art-4d5e195e98754695a346e812957c8a2a |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-17T23:48:54Z |
| publishDate | 2021-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-4d5e195e98754695a346e812957c8a2a2022-12-21T21:28:13ZengDove Medical PressJournal of Asthma and Allergy1178-69652021-05-01Volume 1449350064597Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, ChinaYu LDeng YHHuang YHKe HJGuo YWu JLLi Yu, Yu-Hong Deng, Yuan-Hui Huang, Hai-Jin Ke, Yong Guo, Jie-Ling Wu Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Jie-Ling Wu; Yong GuoDepartment of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, 511400, Guangdong, People’s Republic of ChinaTel +86 20 39151521Email jieling3861@163.com; geyong084@163.comPurpose: Evidence on the role of the gut microbiota in atopic dermatitis is inconsistent as human intestinal microbiota is influenced by geography. This cross-sectional study therefore aimed to compare differences in the gut microbiota of infants with atopic dermatitis and healthy infants in Guangzhou, China, by analyzing their stool.Patients and Methods: The composition of the intestinal microbiota was analyzed from the stool samples of 20 infants with atopic dermatitis (AD group) and 25 healthy infants (non-AD group) (1– 6 months old), using full-length 16S rRNA gene sequencing. The Wilcoxon test was used to analyze the relative abundance of bacteria by phylum, family, genus, and species between groups; microbial community richness and diversity were compared between the two groups.Results: There were no significant differences in the microbial community richness and diversity between the two groups. At the phylum level, 11 bacterial phyla were found; most sequences belonged to one of the three dominant bacterial phyla – Firmicutes, Proteobacteria, and Bacteroidetes. The top 10 microbes at the phylum, family, and genus levels showed no significant changes in their composition within the gut microbiota between the AD and non-AD groups. A decrease in the ratio of the Streptococcus genus was found in atopic dermatitis group when compared with healthy controls (p=0.048).Conclusion: A decrease in the abundance of Streptococcus was found in children with AD. The role of Streptococcus in the development of AD needs to be confirmed in a large cohort study.Keywords: allergy, infant, gut microbiome, Streptococcushttps://www.dovepress.com/comparison-of-gut-microbiota-between-infants-with-atopic-dermatitis-an-peer-reviewed-fulltext-article-JAAallergyinfantgut microbiomestreptococcus |
| spellingShingle | Yu L Deng YH Huang YH Ke HJ Guo Y Wu JL Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China Journal of Asthma and Allergy allergy infant gut microbiome streptococcus |
| title | Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China |
| title_full | Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China |
| title_fullStr | Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China |
| title_full_unstemmed | Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China |
| title_short | Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China |
| title_sort | comparison of gut microbiota between infants with atopic dermatitis and healthy controls in guangzhou china |
| topic | allergy infant gut microbiome streptococcus |
| url | https://www.dovepress.com/comparison-of-gut-microbiota-between-infants-with-atopic-dermatitis-an-peer-reviewed-fulltext-article-JAA |
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